TABLE 2.

HSP inhibitors of Leishmania^a

Inhibitor	Target HSP	Organism	IC50	Reference(s)
Ap5A	HSP78	L. donovani	15 μM	35
CKI-7	CK	L. donovani	>100 μM	159
D4476	CK	L. donovani	30 μM	159
EGCG	HSP70	L. braziliensis	278.8 μM	160
Geldanamycin	HSP83	L. amazonensis	0.2 μM	33
IC261	CK	L. donovani	78 μM	159
Liposomal 17-AAG	HSP83	L. amazonensis	0.006 nM	148
	HSP83	L. braziliensis	65 nM	145
Novobiocin	HSP83	L. donovani	242 μg/ml	142, 161
PBCANP-polymyxin B	HSP70	L. amazonensis	4.6 μM	162
Polymyxin B	HSP70	L. infantum	169 nM	162
	HSP70	L. amazonensis	59.2 μM	162
17-AAG	HSP83	L. braziliensis	65 nM	34
	HSP83	L. amazonensis	65 nM	34
	HSP83	L. major	79 nM	34
17-DMAG	HSP83	L. amazonensis	0.0861 μM	33

^aAbbreviations used in table: Ap5A, P1, P5-di(adenosine-5′)-penta-phosphate ammonium; CK, casein kinase; EGCG, epigallocatechin-3-gallate; PBCANP, poly(n-butylcyanoacrylate) nanoparticles; 17-AAG, 17-allylamino-17-demethoxygeldanamycin.