Table 2.
FPF, MMAD, ED and FPD of DPI formulations of CUR and PTX using the RS01 HR device.
| Formulation | CUR Only | 75CUR:25PTX | 50CUR:50PTX | 25CUR:75PTX | PTX Only | |||
|---|---|---|---|---|---|---|---|---|
| CUR | PTX | CUR | PTX | CUR | PTX | |||
| FPF (%) | 69.5 ± 1.0 | 64.7 ± 7.8 | 69.6 ± 3.5 | 65.6 ± 2.2 | 59.8 ± 4.5 | 55.8 ± 7.0 | 53.1 ± 5.9 | 60.4 ± 1.5 |
| MMAD (µm) | 3.00 ± 0.05 | 3.12 ± 0.04 | 2.74 ± 0.05 | 2.64 ± 0.09 | 2.78 ± 0.05 | 2.82 ± 0.12 | 2.89 ± 0.13 | 2.85 ± 0.10 |
| ED (µg) | 6392.6 ± 254.6 | 4887.6 ± 195.0 | 1755.8 ± 37.0 | 3557.0 ± 150.0 | 3429.4 ± 140.4 | 1600.0 ± 40.0 | 5263.0 ± 160.0 | 6044.2 ± 184.2 |
| FPDEM (µg) | 4442.86 ± 64.0 | 3162.3 ± 381.2 | 1235.9 ± 62.1 | 2333.3 ± 78.2 | 2050.8 ± 154.2 | 892.8 ± 112 | 2794.7 ± 310.3 | 3650.7 ± 91.0 |
n = 3, mean ± SD; FPF: fine particle fraction; MMAD: mass median aerodynamic diameter; ED: emitted dose; FPDEM: fine particle emitted dose.