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. 2020 Dec 23;19(1):1. doi: 10.3390/md19010001

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effects of 4-PSB-2 on the autophagy markers expression in oAβ_1-42-induced ARPE-19 cells. The experimental design is shown in Figure 3A. (A) The expressions of BECLIN 1, LC3B I, LC3B II, and p62 in ARPE-19 cells were assessed by Western blotting. (B–E) Quantitative analysis of the expressions of BECLIN 1, LC3B I, LC3B II, and p62 in ARPE-19 cells treated with the 4-PSB-2 and/or oAβ_1-42. (B–D) The expression levels of BECLIN 1, LC3B I, and LC3B II were not significantly different between the groups after oAβ_1-42 and/or 4-PSB-2 treatment. (E) The expression of p62 in the oAβ_1-42 group was significantly decreased compared to the control group but was not rescued by 4-PSB-2 treatment. The results were plotted as means ± SEMs, * indicates p ≤ 0.05 between the groups.