Table 1.

Studies investigating role of various locally delivered fibre systems in the treatment of periodontal disease in the past 10 years.

Drug Delivery System Employed	Author, Year, and Ref. No	Drug Used	Trade Name of the Drug If Mentioned	Treatment Design	No. of Subjects in the Study	Duration of the Study (Days)	Major Outcome of the Study
Fibres	Meharwade et al., [24] 2014	TET impregnated collagen fibres	Periodontal Plus AB	Split mouth design study	90 sites from 30 patients	45	Local treatment with Periodontal Plus AB showed significant gain in CAL and reduction in probing depths. Also after treatment, GCF leptin levels significantly reduced in this group at day 15 but were increased almost to the pre-treatment levels on day 45 of evaluation. Concluded: nonsurgical periodontal therapies were not effective in maintaining stable reduction in the GCF leptin level even though there was significant reduction in pocket depths and CAL gain.
	F.Y. Khan et al. [24] (2015)	Resorbable collagen-based TET fibres	Periodontal Plus AB fibres	In-vivo study	40	90	Over the 3-month observational period, TET fibres demonstrated better results compared to the control group.
	Sachdeva S. et al. [23] (2011)	Biodegradable TET fibre	Periodontal Plus ABTM	Split mouth design	35	90	Combined antimicrobial and mechanical debridement therapy has shown better results as compared with SRD alone.
	Gill J.S. et al. [27] (2011)	TET fibres and a xanthan based CHX gel	Periodontal Plus AB® and Chlosite®	Randomized split mouth design	30	90	TET fibres are better (they had significant gain in CAL and reduction in probing depths) than CHX gel for treatment of chronic periodontitis.
	Shivojot Chhina et al. [26] (2015)	TET fibres	Periodontal Plus AB®	A RCT	30	90	More favourable outcome in both the clinical and biochemical variables when SRD was combined with LDD of TET fibres - reduction in the Alpha-2-macroglobulin levels in GCF.