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. 2021 Jan 18;14:227–240. doi: 10.2147/DMSO.S289712

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© 2021 Zhang et al.

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(A) Protein expression analysis of p-AMPK, AMPK, p-ACC and ACC in low-glucose HK-2 cells (NC), high-glucose HK-2 cells (HG), high-glucose plus empagliflozin-treated HK-2 cells (HG+Em), and high-glucose plus empagliflozin plus compound C HK-2 (HG+Em+CC) cells. (B) Histogram of p-AMPK, AMPK, p-ACC and ACC expression. (C and D) Histogram of the p-AMPK/AMPK and p-ACC/ACC ratios. (E) Representative images and of immunofluorescence staining for AdipoR1. All images are magnified 200x. (F) Cumulative optical density values for AdipoR1 *p<0.05 vs. NC; ^&p<0.05 vs. HG; ^#p<0.05 vs. HG+Em.