Table 2.
Correlations of LARGE1 Expression and Chemotherapy with Overall Survival in Different Subgroups of Stage I–III NSCLC Patients at Multivariate Analyses
| Parameters | HR | 95% CI | P-value | |
|---|---|---|---|---|
| TCGA | ||||
| LARGE1 in patients without ACT | 0.922 | 0.650 | 1.308 | 0.649 |
| LARGE1 in patients with ACT | 0.196 | 0.047 | 0.810 | 0.024 |
| ACT in patients with low LARGE1 expression | 0.562 | 0.403 | 0.783 | 0.001 |
| ACT in patients with high LARGE1 expression | 0.103 | 0.020 | 0.515 | 0.006 |
| Interaction of adjuvant chemotherapy and LARGE1 | 0.222 | 0.052 | 0.950 | 0.042 |
| Combination of ACT and LARGE1 expression | ||||
| Low LARGE1/ACT vs nonACT | 0.592 | 0.432 | 0.813 | 0.001 |
| High LARGE1/ACT vs nonACT | 0.124 | 0.031 | 0.505 | 0.004 |
| GSE42127 | ||||
| LARGE1 in patients without ACT | 0.604 | 0.304 | 1.203 | 0.151 |
| LARGE1 in patients with ACT | 0.067 | 0.015 | 0.307 | 0.001 |
| ACT in patients with low LARGE1 expression | 1.973 | 0.621 | 6.272 | 0.249 |
| ACT in patients with high LARGE1 expression | 0.175 | 0.052 | 0.589 | 0.005 |
| Interaction of adjuvant chemotherapy and LARGE1 | 0.152 | 0.032 | 0.721 | 0.018 |
| Combination of ACT and LARGE1 expression | ||||
| Low LARGE1/ACT vs nonACT | 2.162 | 0.884 | 5.285 | 0.091 |
| High LARGE1/ACT vs nonACT | 0.188 | 0.058 | 0.610 | 0.005 |
| GSE14814 | ||||
| LARGE1 in patients without ACT | 1.119 | 0.447 | 2.797 | 0.811 |
| LARGE1 in patients with ACT | 0.299 | 0.100 | 0.897 | 0.031 |
| ACT in patients with low LARGE1 expression | 1.094 | 0.413 | 2.903 | 0.856 |
| ACT in patients with high LARGE1 expression | 0.179 | 0.062 | 0.517 | 0.002 |
| Interaction of adjuvant chemotherapy and LARGE1 | 0.278 | 0.072 | 1.078 | 0.064 |
| Combination of ACT and LARGE1 expression | ||||
| Low LARGE1/ACT vs nonACT | 0.837 | 0.382 | 1.835 | 0.657 |
| High LARGE1/ACT vs nonACT | 0.320 | 0.134 | 0.766 | 0.011 |