Table 2. Comparison of different types of IRT.
| Phlebotomy N (%)/ Median (range) |
Chelation N (%)/ Median (range) |
Chelation+Phlebotomy N (%)/ Median (range) |
P value | |
|---|---|---|---|---|
| No. of patients | 10 (6.7) | 61 (40.9) | 78 (52.3) | - |
| Age | 6 (3–8) | 6 (1–16) | 8 (1–18) | 0.086 |
| Pre-IRT ferritin | 2010 (1216–2830) | 2230 (1341–7660) | 2775 (866–8921) | 0.008 |
| Pre-IRT Ferritin | - | - | - | - |
| <2500 ng/ml | 7 (70) | 37 (61) | 31 (40) | 0.022 |
| ≥2500 ng/ml | 3 (30) | 24 (39) | 47 (60) | |
| Lucarelli risk group | - | - | - | - |
| Class 1 | 1 (10) | 3 (5) | - | 0.136 |
| Class 2 | 5 (50) | 19 (31) | 29 (37) | |
| Class 3 | 4 (40) | 39 (64) | 49 (78) | |
| Start of IRT from aHSCT (mo) | 19 (5–41) | 14 (6–53) | 15 (5–42) | 0.352 |
| Duration of IRT (mo) | 50 (20–91) | 32 (3–136) | 51 (5–133) | <0.001 |
| Ferritin reduction (ng/ml/mo) | 87 (33–195) | 130 (17.0–1012) | 147 (27.7–1427) | 0.038 |
| % ferritin reduction/mo | 4 (2.1–15.2) | 5.9 (0.8–15.3) | 5.5 (1.6–17.3) | 0.427 |
| Target ferritin achieved | - | - | - | - |
| <300 | 6 (60) | 26 (43) | 27 (35) | 0.249 |
| <500 | 8 (80) | 38 (62) | 42 (54) | 0.228 |
| Time to target ferritin | - | - | - | - |
| <300ng/ml | 73 (26–95) | 27 (3–136) | 55 (12–123) | 0.009 |
| <500ng/ml | 48 (33–62) | 54 (23–79) | 77 (39–100) | 0.018 |
| Median follow up (mo) | 78 (57–135) | 74 (37–151) | 95 (38–182) | 0.013 |