Table 4. Factors affecting response to IRT.
| Univariate | Forward Multivariate | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age (years) | 1.1 | 1.01–1.20 | 0.017 | - | - | - |
| Gender—Male | 1.4 | 0.68–2.68 | 0.386 | - | - | - |
| Pesaro risk group—Class 3 | 2.2 | 1.07–4.34 | 0.031 | - | - | - |
| No. of transfusions pre-aHSCT—>50 | 3.3 | 1.55–7.11 | 0.002 | 2.3 | 1.04–5.25 | 0.040 |
| Ferritin pre IRT (ng/ml)—≥2500 | 4.4 | 2.18–8.87 | <0.001 | 3.3 | 1.60–6.95 | 0.001 |
| Initial liver size—>2cms | 1.8 | 0.81–4.02 | 0.149 | - | - | - |
| Type of IRT—Chelation (ref) | - | - | - | |||
| Phlebotomy alone | 0.4 | 0.08–2.22 | 0.289 | |||
| Chelation + Phlebotomy | 1.5 | 0.77–2.80 | 0.318 | |||
| Start of IRT from aHSCT (months) | 1.0 | 0.98–1.06 | 0.353 | - | - | - |
| Duration of IRT (months) | 1.0 | 0.99–1.02 | 0.747 | - | - | - |