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. 2020 Dec 23;13(1):12. doi: 10.3390/pharmaceutics13010012

Figure 4.

Figure 4

Serum levels of MTK after MTK film application. (A) Montelukast (MTK) concentration (high dose = 10 mg/kg/d; low dose = 3.3 mg/kg/d) in the serum decreases over 7 h. (B) Samples were taken approximately 7 h after last oral application of MTK by cardiac puncture. Samples were analyzed for MTK concentration by HPLC–MS/MS. There is a dose-dependent increase in serum levels of MTK. (C) After long-term treatment the serum concentration of MTK after 7 h is significantly higher than after single dose treatment with a dose of 10 mg/kg/d. (D) Pooled samples (n = 14–15 per group) were analyzed for MTK concentration by HPLC–MS/MS. There is a dose-dependent increase in the MTK concentration in the CSF. Data are shown as mean +/− SEM. One-way ANOVA with Bonferroni post-hoc test or Student’s t-test was performed. p values of p < 0.0001 and p < 0.001 were considered extremely significant (**** or ***), p < 0.01 very significant (**), and p < 0.05 significant (*).