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. 2020 Dec 23;10(1):12. doi: 10.3390/cells10010012

Figure 1.

Figure 1

Domains and functions of HDAC6. HDAC6 is the largest protein of the HDAC family, with 1215 amino acid residues. ZnF-UB (zinc-finger ubiquitin binding) is a high-affinity ubiquitin-binding motif, and DAC (deacetylase) (1 and 2) is the domain with deacetylase activity. Targets for DAC1 and DAC2 are based on work largely done in Drosophila [13]. Additional targets include survivin, β-catenin, peroxiredoxin, and Miro1. NES = nuclear export sequences, DMB = dynein motor binding, SE14 = Ser-Glu tetradecapeptide repeating domain [9]. NES1 (Aa: 67–76), DAC1 (Aa: 87–447), DAC2 (Aa: 482–800), SE14 (Aa: 884–1022), NES2 (Aa: 1049–1058), ZnF-UB (Aa: 1131–1192) [9].