Table 2.
Clinical symptoms and laboratory findings at initial presentation for patients with positive (SPG) and negative (SNG) results severe fever with thrombocytopenia syndrome using RT-PCR.
| Variable | SPG (n = 62) | SNG (n = 138) | p-Value |
|---|---|---|---|
| Fever (n) | 55 (90.2) | 89 (69.0) | 0.001 |
| Febrile duration (day) | 4.7 (±3.5) | 3.3 (±3.7) | 0.031 |
| Fever peak (°C) | 38.5 (±0.8) | 38.4 (±1.5) | 0.356 |
| Chill | 26 (42.6) | 48 (37.2) | 0.475 |
| Fatigue | 12 (19.7) | 33 (25.6) | 0.371 |
| Headache | 17 (27.9) | 27 (20.9) | 0.290 |
| Myalgia | 26 (42.6) | 44 (34.1) | 0.256 |
| Dizziness | 12 (19.7) | 12 (9.3) | 0.045 |
| Poor oral intake | 25 (41.0) | 10 (7.8) | <0.001 |
| Nausea | 18 (29.5) | 14 (10.9) | 0.001 |
| Vomiting | 7 (11.5) | 12 (9.3) | 0.641 |
| Abdominal pain | 4 (6.6) | 18 (14.0) | 0.137 |
| Diarrhea | 25 (41.0) | 16 (12.4) | <0.001 |
| Hematochezia | 0 (0.0) | 2 (1.6) | 0.332 |
| Hematuria | 0 (0.0) | 8 (6.2) | 0.047 |
| Cough | 2 (3.3) | 18 (14.0) | 0.025 |
| Sputum | 2 (3.3) | 10 (7.8) | 0.237 |
| Hemoptysis | 2 (3.3) | 1 (0.8) | 0.196 |
| Dyspnea | 2 (3.3) | 7 (5.4) | 0.515 |
| Convulsion Altered mentality |
0 (0.0) 11 (17.7) |
0 (0.0) 10 (7.8) |
0.041 |
| Lymphadenopathy | 16 (25.8) | 1 (0.8) | <0.001 |
| Hemorrhagic plaque | 0 (0.0) | 3 (2.3) | 0.226 |
| WBC (cells/μL) | 2554 (±2235) | 6659 (±5494) | <0.001 |
| ANC (cells/μL) | 1593 (±1876) | 4757 (±5010) | <0.001 |
| Lymphocyte fraction (%) | 36.1 (±16.4) | 25.5 (±15.8) | <0.001 |
| Hb (g/dL) | 14.0 (±2.1) | 13.33 (±3.5) | 0.130 |
| Hematocrit (%) | 39.9 (±6.5) | 38.1 (±6.4) | 0.084 |
| Platelet (cells/μL) | 91982 (±42,698) | 125050 (±81,418) | <0.001 |
| CRP (mg/dL) | 1.2 (±2.70) | 9.2 (±9.94) | <0.001 |
| PT (INR) | 1.25 (±1.35) | 1.92 (±8.75) | 0.574 |
| aPTT (sec) | 41.8 (±12.5) | 35.3 (±11.3) | 0.001 |
| Albumin (g/dL) | 3.7 (±0.5) | 3.6 (±0.7) | 0.243 |
| AST (IU/L) | 167 (±292) | 237 (±947) | 0.595 |
| ALT (IU/L) | 72 (±85) | 162 (±680) | 0.321 |
| LDH (IU/L) | 1022 (±1274) | 1066 (±1541) | 0.856 |
| CK (IU/L) | 1062 (±1736) | 431 (±821) | 0.014 |
| BUN (mg/dL) | 17.5 (±18.8) | 21.3 (±18.9) | 0.195 |
| Creatinine (mg/L) | 1.1 (±0.6) | 1.5 (±1.3) | 0.025 |
| MODS | 2.4 (±2.5) | 2.7 (±2.8) | 0.463 |
p values are derived from a two sample t-test for continuous data and chi-square test for categorical data. Continuous data are presented as means and standard deviations; categorical data are presented as counts and percentages. Abbreviation: WBC = white blood cell, ANC = absolute neutrophil count, Hb = hemoglobin, CRP = C-reactive protein, PT = prothrombin time, INR = international normalized ratio, aPTT = activated partial thromboplastin time, AST = aspartate aminotransferase, ALT = alanine aminotransferase, LDH = lactate dehydrogenase, CK = creatinine kinase, BUN = blood urea nitrogen, MODS = multiple organ dysfunction score.