Table 3.
Comparison of amino acids between responders and non-responders. Amino acids profile of responders (n = 12) and non-responders (n = 10). Group differences were analyzed by GEE after adjusting confounding effect of anticonvulsants. R: responders; NR: non-responders.
| Time (month) | β | SE | p | Time (month) | β | SE | p | ||
|---|---|---|---|---|---|---|---|---|---|
| Phenylalanine | 0 | 0.18 | 3.99 | 0.964 | Arginine | 0 | 1.52 | 1.06 | 0.154 |
| 3 | −3.35 | 1.78 | 0.060 | 3 | 0.63 | 1.08 | 0.560 | ||
| 6 | −11.94 | 3.74 | 0.001 *** | 6 | 0.83 | 0.32 | 0.010 ** | ||
| 9 | −3.81 | 1.63 | 0.019 * | 9 | 0.83 | 0.76 | 0.272 | ||
| 12 | 0.21 | 3.00 | 0.943 | 12 | 0.74 | 0.46 | 0.107 | ||
| Tyrosine | 0 | 4.84 | 7.65 | 0.527 | Phenylalanine | 0 | −0.04 | 0.09 | 0.618 |
| 3 | −4.09 | 5.68 | 0.472 | /Tyrosine | 3 | −0.06 | 0.18 | 0.719 | |
| 6 | −0.99 | 2.38 | 0.677 | 6 | −0.30 | 0.06 | 0.000 **** | ||
| 9 | 1.38 | 4.20 | 0.743 | 9 | −0.12 | 0.08 | 0.144 | ||
| 12 | −7.21 | 3.77 | 0.056 | 12 | 0.21 | 0.06 | 0.000 **** | ||
| Glycine | 0 | 38.49 | 25.29 | 0.128 | Alanine | 0 | −27.17 | 44.74 | 0.544 |
| 3 | 92.61 | 25.09 | 0.000 **** | 3 | −13.96 | 38.93 | 0.720 | ||
| 6 | 154.21 | 58.87 | 0.009 ** | 6 | −13.97 | 32.42 | 0.666 | ||
| 9 | 77.63 | 38.82 | 0.046* | 9 | 15.19 | 21.28 | 0.475 | ||
| 12 | 53.38 | 33.84 | 0.115 | 12 | 28.74 | 25.08 | 0.252 | ||
| Proline | 0 | −1.84 | 33.52 | 0.956 | Valine | 0 | −8.54 | 29.85 | 0.775 |
| 3 | −0.04 | 31.20 | 0.999 | 3 | −23.79 | 20.00 | 0.234 | ||
| 6 | −7.89 | 21.46 | 0.713 | 6 | −12.92 | 15.43 | 0.402 | ||
| 9 | −23.27 | 15.74 | 0.139 | 9 | −21.57 | 10.83 | 0.046 * | ||
| 12 | −37.73 | 30.29 | 0.213 | 12 | −21.74 | 18.87 | 0.249 | ||
| Leucine | 0 | −9.71 | 22.42 | 0.665 | Ornithine | 0 | 9.72 | 4.70 | 0.039 * |
| -Isoleucine | 3 | −58.47 | 8.09 | 0.000 **** | 3 | −7.56 | 2.82 | 0.007 ** | |
| 6 | −15.30 | 10.54 | 0.147 | 6 | −5.79 | 2.71 | 0.033 * | ||
| 9 | −37.16 | 8.81 | 0.000 **** | 9 | −6.91 | 9.64 | 0.473 | ||
| 12 | −36.19 | 13.60 | 0.008 ** | 12 | 3.15 | 4.83 | 0.515 | ||
| Methionine | 0 | −2.34 | 3.26 | 0.473 | Citrulline | 0 | −3.28 | 3.06 | 0.284 |
| 3 | −4.81 | 2.82 | 0.088 | 3 | −3.58 | 2.18 | 0.101 | ||
| 6 | −1.38 | 2.90 | 0.635 | 6 | −2.28 | 2.35 | 0.332 | ||
| 9 | 0.57 | 1.19 | 0.629 | 9 | −1.91 | 3.02 | 0.528 | ||
| 12 | −2.49 | 1.64 | 0.129 | 12 | 1.17 | 2.26 | 0.603 | ||
| Glutamic acid | 0 | −3.61 | 12.51 | 0.773 | Homocysteine | 0 | −0.03 | 0.48 | 0.946 |
| 3 | −20.97 | 14.72 | 0.154 | 3 | −0.44 | 0.94 | 0.640 | ||
| 6 | 5.27 | 10.47 | 0.615 | 6 | 0.55 | 1.18 | 0.643 | ||
| 9 | 6.36 | 11.81 | 0.590 | 9 | −1.42 | 0.64 | 0.027 * | ||
| 12 | 17.12 | 10.88 | 0.116 | 12 | −0.69 | 1.09 | 0.524 |
β: regression weight; SE: Standard error; * p < 0.05, ** p < 0.01, *** p < 0.05, **** p < 0.001.