Table 1.
Comparison of selected assays for COVID-19 detection based on the execution time, sensitivity, specificity, LOD, and analyzed sample.
| Immunoassays (Antibody) | Test/Author | Time (min) | Sensitivity | Specificity | LOD | Sample |
| Li et al. [21] | 15 | 88.66% | 90.63% | - | Whole blood, serum, plasma | |
| Pan et al. [22] | 15 | 92.9% intermediate stage, 96.8% late stage | - | - | Whole blood, serum, plasma | |
| BioMedomics [23] | 10–15 | 100% | ~99% | - | Whole blood, serum, plasma | |
| Pharmact company [24] | 20 | 98.2% | 99.7% | - | Whole blood, serum | |
| Chembio diagnostics [25] | 15–20 | 96% | 98.7 | - | Whole blood, serum, plasma | |
| Immunoassays (Antigen) | CareStart [38] | 10 | 88.4% | 100% | 8 × 102–6.4 × 103 TCID50/mL | Nasopharyngeal |
| Panbio [39] | 10 | 91% | 100% | 2.5 × 101.8 TCID50/mL | Nasopharyngeal | |
| Rapid Response [40] | 15 | 94% | 100% | - | Nasopharyngeal, oropharyngeal | |
| Sofia [43] | 15 | 96% | 100% | - | Nasopharyngeal | |
| Standard Q [41] | 20 | 96% | 99% | - | Nasopharyngeal | |
| Wantai kit [42] | 94% | 98% | 20 pg/mL | Nasopharyngeal, oropharyngeal | ||
| BD Veritor [44] | 15 | 84% | 100% | 1.4 × 102 TCID50/mL | Nasopharyngeal, oropharyngeal | |
| Rapid PCR | Xpert Xpress [61] | 25 | 99.4% | 96.8% | - | Nasopharyngeal swab, nasal swab, and nasal wash/aspirates |
| QIAstat-Dx [63] | 60 | 95% | 100% | 500 copies/mL | nasopharyngeal swabs | |
| NxTAG COV [64,108] | 60 | 97.8% | 100% | - | Nasopharyngeal | |
| VereCoV OneMix [66] | 120 | - | - | 20 copies/mL | Nasopharyngeal | |
| VERI-Q Kit [67] | 55 | - | - | 8.9–9 copies/reaction | nasopharyngeal, oropharyngeal, sputum specimens | |
| Isothermal amplification | Yang et al. [83] | 30 | - | 99% | 1000 copies/mL | Nasopharyngeal |
| El-Tholoth et al. [84] | 50 | 100% | - | 7 copies/reaction | Nasal swab | |
| ID NOW [90] | 13 | 95% | 97.9% | 125 copies/mL | Nasal, Throat, Nasopharyngeal | |
| Cue™ COVID-19 [93] | 25 | 99% | 98% | 20 copies/sample | nasal swab | |
| CRISPR-Cas | DETECTR [104] | 40 | - | - | 10 copies/µL | Nasopharyngeal, oropharyngeal, mid-turbinate nasal swabs, anterior nasal swabs, nasopharyngeal wash/aspirate and nasal aspirate |
| Sherlock [101,109] | 60 | 100% | 100% | 6.75 copies/µL | nasopharyngeal, oropharyngeal, bronchoalveolar lavage | |
| iSCAN [106] | 60 | - | - | 10 copies/reaction | Oropharyngeal, nasopharyngeal |