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. 2021 Jan 22;16(1):e0244933. doi: 10.1371/journal.pone.0244933

Table 2. Sociodemographic, previous medical history and current pregnancy information in women undergoing massive transfusion for major obstetric haemorrhage.

UK n = 162 Australia n = 61 Italy n = 99 the Netherlands n = 179 France n = 126 Denmark n = 288 P-value
National denominator 787,105 302,666 458,995 270,101 182,309 349,998
Incidence per 100,000 maternities 20·6 (17·5–24·0) 20·2 (15·4–25·9) 21·6(17·5–26·3) 66·3 (56·9–76·7) 69·1 (57·9–82·3) 82·3 (73·1–92·4)
Age Mean (Std) 33 (5·9) 33 (5·3) 35 (6·1) 32 (5·3) 33 (5·9) 32 (5·4) <0·001
BMI Median (IQR) 25 (22–29) 25 (21–28) 23 (21–25) 23 (21–26) 24 (21–27) 23 (21–27) <0·001
Previous medical history                          
Parity Nulliparous 60 (37·3) 20 (32·8) 48 (48·5) 84 (46·9) 56 (44·8) 128 (44·8) 0·185
Multiparous 101 (62·7) 41 (67·2) 51 (51·5) 95 (53·1) 69 (55·2) 158 (55·2)
Missing 1 0 0 0 1 2
Previous caesarean section None 35 (34·3) 25 (61) 23 (46·9) 51 (53·7) 38 (55·9) 77 (48·1) 0·020
Yes 67 (65·7) 16 (39) 26 (53·1) 44 (46·3) 30 (44·1) 83 (51·9)
Nulliparous 60 20 48 84 56 128
Missing 0 0 2 0 2 0
Number of previous caesarean section 0 35 (34·3) 25 (61) 23 (46·9) - - 38 (55·9) - - 0.036
1 38 (37·3) 10 (24·4) 16 (32·7) - - 21 (30·9) - -
2+ 29 (28·4) 6 (14·6) 10 (20·4) - - 9 (13·2) - -
Nulliparous 60 20 48 - - 56 - -
Missing 0 0 2 2
Previous postpartum haemorrhage None 78 (76·5) 29 (85·3) 41 (91·1) 86 (91·5) 64 (92·8) - - 0·007
Yes 24 (23·5) 5 (14·7) 4 (8·9) 8 (8·5) 5 (7·2) - -
Nulliparous 60 20 48 84 56 - -
Missing 0 7 6 1 1 - -
Current pregnancy                          
Hypertension prior to pregnancy or current problem None 161 (99·4) 59 (96·7) 94 (94·9) 153 (85·5) 124 (99·2) - - <0·001
Yes 1 (0·6) 2 (3·3) 5 (5·1) 26 (14·5) 1 (0·8) - -
Missing 0 0 0 0 1 - -
Infection in current pregnancy No 161 (99·4) 56 (94·9) 99 (100) 179 (100) 117 (97·5) - - 0·006*
Yes 1 (0·6) 3 (5·1) 0 (0) 0 (0) 3 (2·5) - -
Missing 0 2 0 0 6 - -
Inherited bleeding disorders No 160 (98·8) 55 (98·2) - - - - 121 (96·8) - - 0·602*
Yes 2 (1·2) 1 (1·8) - - - - 4 (3·2) - -
Missing 0 5 - - - - 1 - -
Multiple pregnancy No 155 (95·7) 58 (95·1) 92 (92·9) 167 (93·8) 108 (85·7) 219 (76) <0·001
Yes 7 (4·3) 3 (4·9) 7 (7·1) 11 (6·2) 18 (14·3) 69 (24)
Missing 0 0 0 1 0 0
Induced None 103 (65·2) 20 (54·1) 56 (73·7) 117 (65·4) 52 (41·6) - - <0·001
Yes 55 (34·8) 17 (45·9) 20 (26·3) 62 (34·6) 73 (58·4) - -
Missing 4 24 23 0 1 - -
Delivery type Vaginal delivery 50 (31·6) 25 (41) 37 (37·4) 104 (58·4) 47 (37·6) 92 (31·9) <0·001
Caesarean delivery 108 (68·4) 36 (59) 62 (62·6) 74 (41·6) 78 (62·4) 196 (68·1)
N/A Pregnancy loss 4   0   0   1   1   0    

*Used Fisher’s exact test.

Missing data were not included in the percentage. A dash indicated that the country did not collect data on that specific variable.