Figure 2. IGF ligand and binding proteins are highly enriched in mesenchymal stem cells (MSCs).
(A) Top eight signaling pathways enriched in transit amplifying cells (TACs) identified by Ingenuity Pathway Analysis. (B) IGF signaling molecules enriched in MSCs. (C–H) RNAscope (red) of Igfbp3 (C and D), Igf2 (E and F), and Igf1r (G and H) in incisors of 1-month-old control mice. Boxes in (C, E, and G) shown magnified in (D, F, and H), respectively. Arrows indicate positive signal. The white dashed lines outline the cervical loop. Scale bars, 100 μm.