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Concept for the cooperativity switch between LL-37 and HNP1. Escherichia coli (beige) or human endothelial cells (pink) treated with LL-37 alone or LL-37 and HNP1 results in low to high relative cytotoxicity, as indicated by the position of the arrow on the dial. When treated with both LL-37 and HNP1, E. coli are synergistically destroyed, whereas human endothelial cells are protected. To see this figure in color, go online.
