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. 2021 Jan 22;12:531. doi: 10.1038/s41467-020-20809-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Stages (S) of commited murine erythropoiesis with FACS-sorted populations including haematopoietic stem and progenitor cells (HSPC), erythroid blast forming units (BFU-E), and colony-forming units (CFU-E). b Average sequence coverage signature of promoter (P) containing fragments (±1 kb) classified as active (n = 7014) or inactive (n = 181) compared to an equivalent number of background regions (Bg). Chromatin marks from mouse erythroid cells show open chromatin (DNaseI), promoters (H3K4me3), active transcription (H3K27ac), enhancers (H3K4me1), and boundaries (CTCF). Background (Bg) signal was calculated by generating random peaks of the same number and size using BEDtools shuffle. RPK reads per kilobase. c Windowed mean 3C interactions (n = 3 independent 3C libraries) over 1.5 Mb (mm9: chr9:106926158-108566246) for six NuTi Capture-C viewpoints with peaky Marginal Posterior Probability of Contact (MPPC) scores (black peaks) and open chromatin (DNaseI). d Average chromatin signal for interacting fragments (prey) of increasing MPPC identified by capturing either active or inactive promoters. e Enrichment of GenoSTAN annotations for interacting fragments with increasing MPPC. Bg: Background, E_S: Enhancer (Strong H3K27ac), E_W: Enhancer (Weak H3K27ac), P_S: Promoter (Strong H3K27ac), P_W: Promoter (Weak H3K27ac), PC: Promoter/CTCF, C₁: CTCF near Promoter/Enhancer, C₂: CTCF. Source data are available in the Source Data file.