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. 2021 Jan 22;11:2118. doi: 10.1038/s41598-021-81253-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ab-31 inhibits integrin-mediated cell adhesion and latent TGFβ activation. (A) The effect of Ab-31 on the adhesion of CHOK1 parental, CHOK1-α5KO-mαvβ1, CHOK1-mαvβ3, and CHOK1-mαvβ5 cells to fibronectin or vitronectin matrix. (B) pan-αv integrin inhibitors suppress latent TGFβ activation in the transfected Mink lung epithelial cells (TMLC) and CHOK1-integrin co-culture system. The effects of Ab-31, MK-0429, and benchmarking mAb-24 on PAI-1 luciferase activity were shown.