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. 2021 Jan 22;12:541. doi: 10.1038/s41467-020-20642-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Rhesus macaques inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were infused with COVID-19 convalescent plasma (I + CP), normal plasma (I + NP), or did not receive plasma (infected). B Concentrations of human IgG antibodies against S1, S2, and N following CP infusion. C Concentrations of human IgM and IgG antibodies against S1, S2, and N in pooled CP pre-infusion. Pseudovirus neutralization of CP pre-infusion and pooled macaque sera post infusion. D Mean viral RNA (+SD) in nasal washes (kinetic data shown derived from independent animals, sample size for experimental groups: n = 4 infected, n = 2 I + CP, and n = 2 I + NP).