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. 2021 Jan 22;12:525. doi: 10.1038/s41467-020-20874-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a IgG and IgE levels in serum of age-indicated control or CKO mice were measured by Elisa, n = 6–8 mice per mouse group, *p < 0.03, **p < 0.001, ***p < 0.006, ****p < 0.002, ns, not significant (p < 0.2), nonparametric Wilcoxon one-way test. b Anti-dsDNA IgG and IgE levels in serum of age-indicated CKO and control mice were measured by Elisa, n = 5–8 mice per mouse group, *p < 0.05, **p < 0.03, ***p < 0.02, nonparametric Wilcoxon one-way test. c Anti-nuclear antigen (ANA) autoantibody in serum of CKO or control mice (7–14 months old) was tested, n = 8 mice per mouse group. Representative data for four mice from each group are shown. None (0/8) of the control mice and 5/8 of CKO mice show positive for ANA. d Anti-glycan IgG and IgM autoantibodies in serum of control or CKO mice were measured by carbohydrate microarray assay. Overlay plots of anti-glycan autoantibody IgG (upper) and IgM (lower) profiles of serum from four control or CKO mice (>7-month-old) are shown. Each symbol represents data of IgG or IgM reacting to an individual glycan antigen for an individual mouse serum. y-axis: the mean values of triplicate microspot detections of individual sera sample for each antigen, x-axis: corresponding ID of glycan antigens. Oligo-mannoses (#8–34), asialo- and aglacto-glycans(#3–6), O-glycan core-based autoantigens (#43–44), Man1Gn2Asn (#8), Man9Gn2Asn (#24), Glc1Man9 (#32), GlcNAc-RB (#36). Information of each glycan antigen is shown in Supplementary Table 6. The mean values of background microspots (Bg) of each staining are shown in the rightmost of X axis in each graph. Box plots in a, b: box draws 75% (upper), 50% (center line), and 25% (down) quartile, the maxima and minima outliers are shown as top and bottom line, respectively.