Table 2.
Significantly altered genes in MDD subjects compared to control subjects in synaptosome (top and bottom 20).
| Gene symbol | Ensemble ID | Locus | Fold change | p Value | q Value |
|---|---|---|---|---|---|
| Top 20 upregulated genes | |||||
| ZFP36 | ENSG00000128016.5_2 | Chr19:39,897,453–399,00,052 | 2.1776576 | 0.0275288 | 0.999912394 |
| C1QB | ENSG00000173369.15_2 | Chr1:22,979,255–22,988,031 | 2.0394579 | 0.0465707 | 0.999912394 |
| CHTF8 | ENSG00000168802.12_3 | Chr16:69,151,913–69,166,487 | 1.8470062 | 0.0174307 | 0.999912394 |
| RASD1 | ENSG00000108551.4_2 | Chr17:17,397,751–17,399,709 | 1.8322651 | 0.0081353 | 0.999912394 |
| CEBPD | ENSG00000221869.4_2 | Chr8:48,649,471–48,651,648 | 1.7427126 | 0.0399716 | 0.999912394 |
| TMEM88B | ENSG00000205116.3_2 | Chr1:1,361,508–1,363,167 | 1.7405742 | 0.0093953 | 0.999912394 |
| KIF19 | ENSG00000196169.14_2 | Chr17:72,322,349–72,351,959 | 1.7176642 | 0.0061926 | 0.999912394 |
| MOG | ENSG00000204655.11_3 | Chr6:29,624,758–29,640,149 | 1.6982876 | 0.0446928 | 0.999912394 |
| S100A9 | ENSG00000163220.10_2 | Chr1:153,330,330–153,333,503 | 1.6963496 | 0.0214211 | 0.999912394 |
| RGS16 | ENSG00000143333.6_2 | Chr1:182,567,758–182,573,543 | 1.6860759 | 0.020914 | 0.999912394 |
| HAPLN2 | ENSG00000132702.12_2 | Chr1:156,589,086–156,595,517 | 1.660522 | 0.0399065 | 0.999912394 |
| CX3CL1 | ENSG00000006210.6_2 | Chr16:57,406,370–57,418,960 | 1.6509677 | 0.0164296 | 0.999912394 |
| GALNT15 | ENSG00000131386.17_2 | Chr3:16,216,156–16,273,499 | 1.6278187 | 0.0268205 | 0.999912394 |
| SLC2A5 | ENSG00000142583.17_3 | Chr1:9,095,166–9,148,537 | 1.6249166 | 0.003212 | 0.999912394 |
| ADAMTS4 | ENSG00000158859.9_2 | Chr1:161,154,098–161,168,846 | 1.6133472 | 0.0502441 | 0.999912394 |
| ADNP2 | ENSG00000101544.8_2 | Chr18:77,866,915–77,905,406 | 1.5810882 | 0.0164974 | 0.999912394 |
| CD68 | ENSG00000129226.13_3 | Chr17:7,482,785–7,485,431 | 1.5771296 | 0.0423986 | 0.999912394 |
| FPR1 | ENSG00000171051.8_3 | Chr19:52,248,425–52,307,363 | 1.5668887 | 0.007887 | 0.999912394 |
| CDC42EP1 | ENSG00000128283.6_4 | Chr22:37,956,454–37,965,412 | 1.5649011 | 0.0222008 | 0.999912394 |
| TYROBP | ENSG00000011600.11_2 | Chr19:36,395,303–36,399,197 | 1.5585077 | 0.022949 | 0.999912394 |
| Top 20 downregulated genes | |||||
| CDH4 | ENSG00000179242.15_4 | Chr20:59,827,482–60,515,673 | 0.7962247 | 0.019576 | 0.999912394 |
| CLDN10 | ENSG00000134873.9_2 | Chr13:96,085,858–96,232,013 | 0.7947775 | 0.0254516 | 0.999912394 |
| N6AMT1 | ENSG00000156239.11_2 | Chr21:30,244,513–30,257,693 | 0.794196 | 0.0192057 | 0.999912394 |
| FUT9 | ENSG00000172461.10_2 | Chr6:96,463,860–96,663,488 | 0.7924129 | 0.0261338 | 0.999912394 |
| FZD8 | ENSG00000177283.7_3 | Chr10:35,927,177–35,931,206 | 0.7911683 | 0.0373176 | 0.999912394 |
| MTA3 | ENSG00000057935.13_2 | Chr2:42,721,709–42,984,087 | 0.7883872 | 0.0229091 | 0.999912394 |
| CISD3 | ENSG00000277972.1_2 | Chr17:36,886,488–36,891,297 | 0.7833351 | 0.0087768 | 0.999912394 |
| WNT7B | ENSG00000188064.9_3 | Chr22:46,316,242–46,373,009 | 0.7770486 | 0.0398209 | 0.999912394 |
| MRPL34 | ENSG00000130312.6_3 | Chr19:17,403,418–17,417,652 | 0.7698633 | 0.0371592 | 0.999912394 |
| ASPDH | ENSG00000204653.9_3 | Chr19:51,014,857–51,017,947 | 0.7658521 | 0.0327412 | 0.999912394 |
| TTPA | ENSG00000137561.4_2 | Chr8:63,961,112–63,998,612 | 0.7616707 | 0.0046591 | 0.999912394 |
| LFNG | ENSG00000106003.12_2 | Chr7:2,552,163–2,568,811 | 0.7578215 | 0.0298689 | 0.999912394 |
| KCNJ14 | ENSG00000182324.6_3 | Chr19:48,958,766–48,970,237 | 0.7523269 | 0.0071809 | 0.999912394 |
| CHST7 | ENSG00000147119.3_2 | ChrX:46,433,219–46,457,843 | 0.7443651 | 0.0226256 | 0.999912394 |
| CYB561D1 | ENSG00000174151.14_4 | Chr1:110,036,674–110,045,554 | 0.7427098 | 0.0254082 | 0.999912394 |
| TEN1 | ENSG00000257949.6_3 | Chr17:73,975,301–73,996,667 | 0.7386488 | 0.0370837 | 0.999912394 |
| CHP1 | ENSG00000187446.11_2 | Chr15:41,523,037–41,574,088 | 0.7310931 | 0.0382482 | 0.999912394 |
| ARNT2 | ENSG00000172379.20_3 | Chr15:80,696,692–80,890,278 | 0.7235799 | 0.0358096 | 0.999912394 |
| ACSS1 | ENSG00000154930.14_2 | Chr20:24,986,866–25,039,616 | 0.7132899 | 0.0013848 | 0.999912394 |
| HES5 | ENSG00000197921.5_2 | Chr1:2,460,184–2,461,684 | 0.5447051 | 0.0328057 | 0.999912394 |