Table 3.
Shift in gene expression ratios between synaptic vs. total fractions in MDD subjects.
| Gene symbol | Ensembl ID | Control (Ct) ratio | MDD ratio | MDD/Ct | p Value |
|---|---|---|---|---|---|
| AC010531.1 | ENSG00000131152.4_4 | 1.109117 | 0.451195 | 0.406806 | 0.020 |
| AC068987.1 | ENSG00000260415.3 | 0.617041 | 1.035928 | 1.678864 | 0.025 |
| AC092835.1 | ENSG00000233757.6_3 | 0.740429 | 0.890826 | 1.203121 | 0.040 |
| ACAD11 | ENSG00000240303.7_3 | 0.442945 | 0.759169 | 1.713913 | 0.043 |
| ACTL6A | ENSG00000136518.16_3 | 0.588869 | 0.83387 | 1.416053 | 0.035 |
| ANKRD20A2 | ENSG00000183148.6_3 | 0.328245 | 0.533641 | 1.625738 | 0.044 |
| AP000350.4 | ENSG00000251357.4_4 | 0.794562 | 0.645044 | 0.811824 | 0.017 |
| APOL4 | ENSG00000100336.17_3 | 0.76277 | 1.415282 | 1.855449 | 0.033 |
| ARHGAP24 | ENSG00000138639.17_2 | 0.856571 | 1.10586 | 1.291032 | 0.028 |
| ATP10B | ENSG00000118322.12_2 | 0.668256 | 0.949887 | 1.421441 | 0.037 |
| BBS4 | ENSG00000140463.13_3 | 0.727548 | 0.934154 | 1.283976 | 0.027 |
| BCL7B | ENSG00000106635.7_2 | 1.074546 | 1.000904 | 0.931467 | 0.042 |
| C14orf119 | ENSG00000179933.5_2 | 0.73052 | 0.86649 | 1.186128 | 0.024 |
| CACNB3 | ENSG00000167535.7_2 | 1.092732 | 0.961579 | 0.879977 | 0.029 |
| CAPN3 | ENSG00000092529.23_3 | 0.618857 | 0.8293 | 1.340051 | 0.042 |
| CDIP1 | ENSG00000089486.16_3 | 1.043427 | 0.963377 | 0.923281 | 0.032 |
| CDK5R2 | ENSG00000171450.5_2 | 0.981479 | 0.925658 | 0.943125 | 0.034 |
| CREM | ENSG00000095794.19_4 | 0.76757 | 0.877173 | 1.142792 | 0.048 |
| CRISPLD1 | ENSG00000121005.8_2 | 0.546605 | 0.845734 | 1.547248 | 0.041 |
| CEP85 | ENSG00000130695.14_2 | 0.770408 | 0.951118 | 1.234563 | 0.038 |
| CNDP2 | ENSG00000133313.14_3 | 1.032092 | 0.902963 | 0.874886 | 0.036 |
| CWC25 | ENSG00000273559.4_2 | 0.732397 | 0.952897 | 1.301066 | 0.047 |
| CX3CL1 | ENSG00000006210.6_2 | 0.649123 | 0.903662 | 1.392127 | 0.013 |
| CYP46A1 | ENSG00000036530.8_2 | 0.988763 | 0.906198 | 0.916496 | 0.038 |
| DAXX | ENSG00000204209.11_4 | 1.068359 | 0.967248 | 0.905358 | 0.021 |
| DDX3Y | ENSG00000067048.16_3 | 0.78034 | 0.833528 | 1.06816 | 0.044 |
| DIABLO | ENSG00000184047.16_3 | 0.835929 | 0.982002 | 1.174744 | 0.043 |
| DNAH9 | ENSG00000007174.17_3 | 0.661659 | 0.889836 | 1.344856 | 0.049 |
| DPH2 | ENSG00000132768.13_2 | 1.084157 | 0.956665 | 0.882405 | 0.016 |
| EFCAB11 | ENSG00000140025.15_3 | 0.785504 | 1.073849 | 1.367084 | 0.039 |
| EHD1 | ENSG00000110047.17_2 | 1.109755 | 0.898865 | 0.809967 | 0.006 |
| ENDOU | ENSG00000111405.8_2 | 1.002033 | 1.600795 | 1.597547 | 0.044 |
| FAM212A | ENSG00000185614.4_2 | 0.936095 | 0.711428 | 0.759995 | 0.025 |
| FAM219A | ENSG00000164970.14_2 | 1.143265 | 1.012943 | 0.886009 | 0.034 |
| FAM78A | ENSG00000126882.12_2 | 1.158076 | 1.008606 | 0.870932 | 0.040 |
| FBXL18 | ENSG00000155034.18_3 | 1.340458 | 1.095543 | 0.81729 | 0.024 |
| FCF1 | ENSG00000119616.11_2 | 0.75 | 1.20057 | 1.600761 | 0.033 |
| FGD1 | ENSG00000102302.7_2 | 1.08939 | 1.007333 | 0.924676 | 0.046 |
| GADD45A | ENSG00000116717.11_2 | 0.898648 | 1.091988 | 1.215146 | 0.045 |
| GALK2 | ENSG00000156958.14_3 | 0.713817 | 0.875241 | 1.226142 | 0.035 |
| GALNT4 | ENSG00000257594.3_3 | 0.565474 | 0.923666 | 1.633437 | 0.032 |
| GDI1 | ENSG00000203879.11_2 | 0.985422 | 0.90179 | 0.915131 | 0.044 |
| GPIHBP1 | ENSG00000277494.1_2 | 0.564343 | 0.769699 | 1.363885 | 0.048 |
| GSG1L | ENSG00000169181.12_4 | 0.885812 | 1.14154 | 1.288693 | 0.003 |
| GUCA1B | ENSG00000112599.8_2 | 0.862628 | 1.521691 | 1.764017 | 0.009 |
| HAUS7 | ENSG00000213397.10_4 | 0.615618 | 0.86666 | 1.407789 | 0.047 |
| HSPA2 | ENSG00000126803.9_3 | 1.29328 | 0.91394 | 0.706684 | 0.041 |
| IGSF21 | ENSG00000117154.11_3 | 0.998621 | 0.940739 | 0.942038 | 0.031 |
| IMMT | ENSG00000132305.20_2 | 0.811733 | 0.939611 | 1.157537 | 0.027 |
| INPP1 | ENSG00000151689.12_2 | 0.702529 | 0.885719 | 1.260758 | 0.018 |
| JMJD4 | ENSG00000081692.12_2 | 0.911505 | 1.218259 | 1.336535 | 0.004 |
| KIAA0040 | ENSG00000235750.9_2 | 0.381431 | 0.789758 | 2.070513 | 0.023 |
| KLHL20 | ENSG00000076321.10_3 | 0.810558 | 1.045121 | 1.289384 | 0.015 |
| KRBA2 | ENSG00000184619.3_3 | 0.856094 | 1.106994 | 1.293075 | 0.001 |
| LACTB2 | ENSG00000147592.8_2 | 0.672986 | 0.93313 | 1.386551 | 0.029 |
| LIMK1 | ENSG00000106683.14_2 | 1.229904 | 1.050647 | 0.854251 | 0.019 |
| LLGL2 | ENSG00000073350.13_2 | 0.529035 | 0.768594 | 1.452823 | 0.029 |
| LRP2 | ENSG00000081479.12_2 | 0.440017 | 0.777273 | 1.766463 | 0.037 |
| LSM1 | ENSG00000175324.9_2 | 0.948025 | 1.037139 | 1.093999 | 0.047 |
| MAP2K2 | ENSG00000126934.13_2 | 1.043799 | 0.978676 | 0.937609 | 0.039 |
| MOG | ENSG00000204655.11_3 | 0.737132 | 0.937363 | 1.271635 | 0.027 |
| MSH6 | ENSG00000116062.14_3 | 0.749917 | 0.972315 | 1.296563 | 0.041 |
| MTA3 | ENSG00000057935.13_2 | 1.279879 | 1.067502 | 0.834065 | 0.015 |
| MTO1 | ENSG00000135297.15_2 | 0.723714 | 0.916889 | 1.266921 | 0.020 |
| NDE1 | ENSG00000072864.14_3 | 0.630604 | 0.935422 | 1.483376 | 0.007 |
| ODC1 | ENSG00000115758.12_3 | 0.948832 | 1.050529 | 1.10718 | 0.021 |
| OSMR | ENSG00000145623.12_3 | 0.492132 | 0.750504 | 1.525004 | 0.015 |
| PARP12 | ENSG00000059378.12_2 | 0.524304 | 0.786383 | 1.499861 | 0.022 |
| PCCB | ENSG00000114054.13_3 | 0.870068 | 0.946768 | 1.088155 | 0.036 |
| PHLDA2 | ENSG00000181649.5_2 | 1.002686 | 0.690281 | 0.688432 | 0.041 |
| PLSCR1 | ENSG00000188313.12_3 | 0.593825 | 0.791404 | 1.332722 | 0.025 |
| PM20D2 | ENSG00000146281.5_2 | 0.834077 | 0.986752 | 1.183046 | 0.043 |
| POPDC3 | ENSG00000132429.9_2 | 0.716706 | 0.938912 | 1.310038 | 0.011 |
| PPARA | ENSG00000186951.16_3 | 0.907818 | 1.409824 | 1.552982 | 0.048 |
| PPIE | ENSG00000084072.16_3 | 0.722037 | 0.916081 | 1.268745 | 0.010 |
| PPP1R18 | ENSG00000146112.11_2 | 1.126685 | 0.970509 | 0.861385 | 0.037 |
| PSENEN | ENSG00000205155.7_3 | 0.79529 | 0.877975 | 1.103969 | 0.040 |
| PTP4A3 | ENSG00000184489.11_4 | 0.96628 | 0.871331 | 0.901738 | 0.044 |
| RBBP4 | ENSG00000162521.18_3 | 0.852028 | 1.003293 | 1.177535 | 0.046 |
| RFT1 | ENSG00000163933.9_3 | 0.881272 | 1.058105 | 1.200657 | 0.025 |
| RGS16 | ENSG00000143333.6_2 | 0.747131 | 1.081041 | 1.446923 | 0.022 |
| RHOQ | ENSG00000119729.11_3 | 1.32783 | 1.141333 | 0.859548 | 0.043 |
| RILPL2 | ENSG00000150977.10_2 | 1.145368 | 1.009566 | 0.881434 | 0.027 |
| RIPK1 | ENSG00000137275.13_2 | 0.795016 | 0.952675 | 1.19831 | 0.016 |
| RNASE4 | ENSG00000258818.3_3 | 0.496841 | 0.945895 | 1.903816 | 0.042 |
| RNF214 | ENSG00000167257.10_3 | 1.022524 | 0.873818 | 0.85457 | 0.004 |
| RPL6 | ENSG00000089009.15_2 | 0.945796 | 1.022728 | 1.081341 | 0.027 |
| S100PBP | ENSG00000116497.17_3 | 0.597426 | 0.997503 | 1.669666 | 0.032 |
| SCO2 | ENSG00000130489.14_3 | 0.898872 | 0.774805 | 0.861975 | 0.020 |
| SEC13 | ENSG00000157020.17_3 | 0.799129 | 0.926857 | 1.159834 | 0.046 |
| SEMA6A | ENSG00000092421.16_2 | 0.733411 | 0.921617 | 1.256617 | 0.036 |
| SH3BP4 | ENSG00000130147.15_3 | 0.782312 | 0.975496 | 1.246939 | 0.015 |
| SHC4 | ENSG00000185634.11_2 | 0.705852 | 1.152284 | 1.632473 | 0.042 |
| SLC39A7 | ENSG00000112473.17_3 | 0.843186 | 0.94314 | 1.118543 | 0.045 |
| SMKR1 | ENSG00000240204.2_2 | 0.938199 | 1.101026 | 1.173553 | 0.034 |
| SMNDC1 | ENSG00000119953.12_2 | 0.673909 | 0.853418 | 1.266369 | 0.033 |
| SPAG1 | ENSG00000104450.12_2 | 0.696272 | 0.947067 | 1.360198 | 0.034 |
| STUM | ENSG00000203685.9_3 | 1.103296 | 1.36013 | 1.232788 | 0.023 |
| SUSD3 | ENSG00000157303.10_3 | 0.944125 | 0.582786 | 0.617277 | 0.017 |
| SYPL2 | ENSG00000143028.8_2 | 0.253054 | 0.164774 | 0.651142 | 0.009 |
| TAF6 | ENSG00000106290.14_3 | 1.070497 | 0.988082 | 0.923012 | 0.022 |
| TAF6L | ENSG00000162227.7_3 | 0.925703 | 0.798461 | 0.862545 | 0.046 |
| TBC1D3 | ENSG00000197681.8 | 0.528187 | 1.078091 | 2.041115 | 0.046 |
| TMEM138 | ENSG00000149483.11_2 | 0.545755 | 0.801324 | 1.468284 | 0.010 |
| TMEM230 | ENSG00000089063.14_2 | 0.870686 | 0.938659 | 1.078069 | 0.038 |
| TMEM250 | ENSG00000238227.7_4 | 1.29612 | 1.078574 | 0.832156 | 0.018 |
| TNFSF13 | ENSG00000161955.16_3 | 0.991214 | 1.133431 | 1.143478 | 0.049 |
| TRAPPC5 | ENSG00000181029.8_3 | 1.232167 | 0.971181 | 0.788189 | 0.037 |
| TRIM16 | ENSG00000221926.11_4 | 0.72783 | 1.020225 | 1.401735 | 0.046 |
| TULP3 | ENSG00000078246.16_3 | 0.823316 | 1.013812 | 1.231377 | 0.045 |
| TVP23C-CDRT4 | ENSG00000259024.6_3 | 0.645766 | 1.116121 | 1.728368 | 0.028 |
| TXNIP | ENSG00000265972.5_2 | 0.798444 | 0.891237 | 1.116217 | 0.049 |
| U2AF1L5 | ENSG00000275895.6_4 | 0.661736 | 0.927801 | 1.40207 | 0.007 |
| ZC3H12A | ENSG00000163874.10_3 | 0.46926 | 0.950929 | 2.026445 | 0.018 |
| ZNF229 | ENSG00000278318.4_3 | 0.903331 | 1.162093 | 1.286453 | 0.035 |
| ZNF334 | ENSG00000198185.11_3 | 0.537001 | 0.790072 | 1.471268 | 0.047 |
| ZNF610 | ENSG00000167554.14_2 | 0.647825 | 0.887647 | 1.370194 | 0.019 |
| ZNF823 | ENSG00000197933.12_3 | 0.694311 | 0.896145 | 1.290696 | 0.047 |
| ZNF84 | ENSG00000198040.10_3 | 0.566025 | 1.072708 | 1.89516 | 0.040 |