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. 2021 Jan 22;11:2121. doi: 10.1038/s41598-021-81486-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Antiplasmodial activity, toxicity and stability profiles of the prioritized hits NCGC00374598 and NCGC00473217. Compound activity profiles for NCGC00374598 (compound 1) and NCGC00473217 (compound 2) against P. falciparum asexual blood stage parasites (black line, circle), as well as P. berghei liver stages in either laboratory A (blue line, squares) or laboratory B (purple line, triangles). Percent inhibition is shown on the Y-axis and compound concentration (Log [M]) is shown on the X-axis. Also shown are activities against P. falciparum Dd2 ABS parasites, in vitro inhibition activity in the P. berghei liver stage development assay (ILSDA), toxicity against mammalian HepG2 cells, and half-life rat liver microsome stability (RLM) values. Mean ± SD values were derived from of at least three independent replicates.