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. 2021 Jan 22;12:549. doi: 10.1038/s41467-020-20832-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Hierarchical clustering of cDNA microarray data comparing the renal gene expression profiles of hypoxic (Hy), normoxic (No), and caloric control (Cc) group E18.5 fetuses (N = 3 per experimental condition). Orange indicates induction, blue repression. Clustering was performed for genes with at least 1.3-fold regulation of hypoxic vs. both normoxic controls; 1way ANOVA; P < 0.05. b, c Relative mRNA values of Ahsg (b) or Apoc2 (c) in E18.5 kidneys (circles) or liver samples (squares) shown as mean ± SEM. N = fetal organs. Kidney and liver samples are analyzed separately. Note the logarithmic scale on the y-axis. d, e Serum fetuin-A levels assessed by ELISA are presented as mean and ± SEM. N = serum samples. No significant changes were observed among normoxic (No), hypoxic (Hy), or caloric control (Cc) E18.5 fetuses (d), nor for their mothers (e). Ordinary one-way ANOVA with Tukey’s multiple comparison test (b–e). Individual P-values are denoted above the comparison lines (b–e). (***P < 0.001; **P < 0.01). Source data are provided as a Source Data file.