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. 2021 Jan 22;12(1):120. doi: 10.1038/s41419-020-03361-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The structure of USP46 subdomains. Residues of the catalytic triad located at the interface between the palm and the thumb subdomains are shown as green sticks (PDB code 5L8H⁴⁰). b A model of USP46 complex based on superposition of the structures of USP46 with covalent ubiquitin (Ub-VME) (PDB code 5L8H⁴⁰) with the non-covalent complex of USP46:WDR20:WDR48 (PDB code 6JLQ³⁹).