Table 2.
Pathways upregulated and downregulated by A3A in M1-polarized macrophages.
| Upregulated | Downregulated |
|---|---|
| Adaptive immune system**** | Peptide elongation/translation**** |
| Cytokine–cytokine receptor**** | Glycolysis-gluconeogenesis* |
| G-protein-coupled receptor**** | Pyruvate metabolism* |
| Interferon alpha-beta**** | PID-HIF1-TF pathway* |
| Antigen processing and presentation**** | Mitochondrial protein** |
| Class-1-MHC mediated**** | Protein metabolism**** |
| Apoptosis** | Pentose phosphate pathway* |
| Chemokines receptors**** | Arginine and proline metabolism* |
| Stress pathway* | Influenza life cycle**** |
| Cytokines pathway** | Influenza viral RNA transcription and replication**** |
| MHC-Class-II antigen presentation*** | Integrin-1 pathway** |
| Death pathway* | Transport of glucose* |
FDR q-val by GO analysis comparing A3A SC vs. A3A KD: * <0.05; ** <0.01; *** <0.001; **** <0.001.