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. 2021 Jan 22;7:22. doi: 10.1038/s41420-020-00381-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Circ-NOLC1 downregulation reduced tumorigenicity in nude mice (A & B). The tumor volumes were smaller in the sh-circ-NOLC1 group than in sh-NC group (C), Circ-NOLC1 expression (D) and ESRP1, RhoA, CDK1 protein level were all downregulated in sh-circ-NOLC1 group than in sh-NC group (E). Comparisons between two groups were analyzed using a two-sided Student’s t test. *p < 0.05.