Table 4.

Genes with significantly increased or decreased gene expression during age between study groups

Age effect (Old/Young)	Increased gene transcript abundance					Decreased gene transcript abundance
DNA repair pathway	BER	DDR	DSB	MMR	NER	BER	DDR	DSB	MMR	NER
Unstimulated GV oocytes						Polb	Exo1	Rad51 Rad23b	Mlh3 Pold3	Ccnh Ercc2 Mms19 Rpa1
IVM-MII oocytes	Smug1 Neil3 Ung	Exo1 TPD1 Xrcc6 Rfc1	Rad21 Rad51d Mre11a	Pms1 Msh3	Xpa Ercc2 Lig1 Brip1					Ercc3 Ercc5
PMSG-stimulated GV oocytes						Parp1 Apex2 Ccno	Top3b H2AFX Xrcc6bp1 Chaf1a	Xrcc3 Xrcc5 Xrcc6 Rad54l Rad51d Rad51	Pms2	Rpa1 Slk Pnkp Lig1 Xpc Poll Ercc2
PMSG-stimulated MII oocytes						Nthl1 Apex2 Neil2	Exo1 Top3a Top3b TDP1 Atm PolM Polq	Bcra1 Bcra2 Rad51 Rad23a Mre11a Xrcc2 Dmc1		Ddb1 Ercc6 Slk Ercc3
AIS-stimulated GV oocytes							Atr			Ccnh Rpa3
AIS-stimulated MII oocytes		PolQ	Dmc1			Lig3 Parp2			Msh3	Rpa1

Young: female mice 5–8 weeks old. Old: female mice 42–45 weeks old. PMSG pregnant mare serum gonadotropin, AIS anti-inhibin serum. DNA repair pathways; base excision repair (BER); double strand break (DSB); mismatch repair (MMR); nucleotide excision repair (NER); DNA damage response (DDR)

Old/young: genes with differentially transcript levels represent the relative transcript abundance in oocytes from old females divided by the relative transcript abundance of the same gene in oocytes from young females. All genes were statistically different (p < 0.05; Mann–Whitney test)