Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 4;29(22):3662–3678. doi: 10.1093/hmg/ddaa258

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

PMC Copyright notice

Kidney defects are present in E17.5 Wbp11^+/− embryos. (A) Anterior view of micro-computed tomography (micro-CT) reconstructions comparing kidney morphology between Wbp11^+/+ and Wbp11^+/− littermates at E17.5. Left kidney is indicated. Graph shows comparison of volume measurements of left and right kidneys in Wbp11^+/+ and Wbp11^+/− littermates at E17.5 (left kidney, ^*^*P = 0.0024; right kidney, ^*^*^*P = 0.0002). Red dots indicate the embryos on the left. (B) Histological sections (sagittal) stained with hematoxylin and eosin of an E17.5 kidney from Wbp11^+/+ (top two panels) and Wbp11^+/− embryos (bottom two panels). Whole kidney micrographs (left) and high magnifications (right) are shown. (C) 3D surface view of the lungs combined with micro-CT reconstruction slice (anterior view). Volume measurements of the lungs from Wbp11^+/+ and Wbp11^+/− littermates at E17.5 (^*^*P = 0.0034). Red dots indicate embryos on the left. (D) 3D surface view of the liver combined with micro-CT reconstruction slice (anterior view). Volume measurements of the livers from Wbp11^+/+ and Wbp11^+/− littermates at E17.5 (^*^*^*P = 0.0001). Red dots indicate embryos on the left. Embryos included in this data are from the second backcross. Kidney, lung and liver volumes were normalized against the embryo weight. Unpaired t-test was performed to determine statistical significance. Scale bars: 2 mm (A), whole kidney = 500 μm and high magnification = 100 μm (B), 5 mm (C, D). Error bars represent standard deviation (SD).