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. 2020 Nov 24;29(22):3631–3645. doi: 10.1093/hmg/ddaa244

Figure 1.

Figure 1

Yeast drugs screenings. (A) Spot assay of mgm1I322M mutant strain on YP medium supplemented with 2% ethanol or 2% glycerol at 37°C. 4 × 104, 4 × 103, 4 × 102 and 4 × 101 cells were present in each serial spot. (B) Petite frequency and (C) oxygen consumption rate normalized to the wild type MGM1 strain of the mgm1I322M mutant strain at 37°C. (D) Spot assay on YP medium supplemented with 2% ethanol and 2% glycerol of the chim3 mutant strains at 28 and 37°C. (E) Petite frequency of the mgm1I322M mutant strain treated with ORMs (32 μm ORM0, 420 nM ORM2, 16 μm ORM 11, 24 μm ORM12, 92 μm OMR14 and 1 μm ORMA) or with DMSO at 28°C. **Denotes P < 0.01; ***denotes P < 0.001.