Table 4.
Summary of the effect of different ORMs on mitochondrial functions in MEFs
| Phenotype | Cell lines | ORM0 | ORM2 | ORM12 | ORM14 | ORMA |
|---|---|---|---|---|---|---|
| Cell viability | ISO1 | |||||
| R445H | b | |||||
| D603H | ||||||
| ATP | ISO1 | |||||
| R445H | b | b | a | |||
| D603H | ||||||
| Mitochondrial morphology glucose | ISO1 | b | b | b | ||
| R445H | ||||||
| D603H | b | b | b | |||
| Mitochondrial morphology galactose | ISO1 | b | c(NEG) | b | b | |
| R445H | ||||||
| D603H | b | b | c(NEG) | b | b | |
| Efficacy |
−Energetics −Morphology |
−Energetics −Morphology |
−Cell viability | −Morphology | −Morphology |
aNot statistically significant trend.
bStatistically significant trend.
cStatistically significant trend in a negative way.