Table 2.
Clinical and biological characteristics of the patients at D0 according to proteinuria staging at D0 (n = 153)
| Stage 1 proteinuria <150 mg/g (n = 21) |
Stage 2 150-500 mg/g (n = 64) |
Stage 3 >500 mg/g (n = 68) |
Kruskal–Wallis test (or exact Chi2 test) |
|
|---|---|---|---|---|
| Clinical | ||||
| Age (years) | 61 [55;79] | 66 [58;79] | 75 [64;84] | 0.02 |
| Women (%) | 43 | 42 | 34 | ns |
| Weight (kg) | 77 [65;92] | 82 [69;95] | 76 [67;91] | ns |
| Height (m) | 1.67 [1.61;1.77] | 1.71 [1.63;1.78] | 1.70 [1.65;1.79] | ns |
| Body Mass index (kg/m2) | 27 [25;29] | 28 [25;31] | 27 [23;29] | ns |
| Medical history | ||||
|
Hypertension (%) Diabetes (%) Chronic kidney disease (%) Active cancer (%) Active smoking (%) |
48 33 5 5 0 |
58 27 16 13 6 |
63 28 22 10 4 |
ns ns ns ns ns |
| Intensive Care Unit (%) | 5* | 17 | 31 | 0.006 |
| Severe cases (%) | 48 | 84$ | 90$ | 0.0002 |
| Thoracic CT-Scanner staging | ||||
|
Normal Minor (< 10%) Mild (10–50%) Severe (> 50%) |
30 10 55 5 |
11 10 65 14 |
13 4 59 24 |
ns ns ns 0.04 |
| Biological | ||||
|
Creatinine (D0)(mg/dL) eGFR (mL/min/1.73 m2) |
0.87 [0.72;0.95] 85 [70;97]* |
0.92 [0.72;1.2] 74 [59;92] |
0.98 [0.82;1.33] 69 [51;85] |
ns 0.02 |
| C-reactive protein (mg/L) | 49 [13;74]* | 78 [26;148]* | 118 [61;169] | 0.0002 |
| Leukocyte count (/mm3) | 5720 [4170;7170] | 6005 [4735;10,025] | 6605 [4875;9150] | ns |
| Lymphocyte count (/mm3) | 940 [763;1399] | 910 [703;1248] | 800 [543;1075] | 0.04 |
| Hemoglobin (g/dL) | 13.2 [12.6;14.3]* | 12.6 [11.1;13.8] | 11.8 [11;13.1] | 0.01 |
| Platelets (x1,000/mm3) | 248 [181;301] | 240 [174;332] | 201 [160;289] | ns |
| Lactate Dehydrogenase (U/L) | 254 [224;290]* | 328 [258;408]$ | 377 [285;555] | 0.00005 |
| D-Dimer (µg/L) | 876 [371;1508] | 952 [560;1609] | 1202 [815;2945] | 0.04 |
| Albumin (g/L) | 38 [33;41]* | 35 [32;39]* | 33 [33;41] | 0.0002 |
| Potassium (mmol/L) | 4.16 [3.80;4.54] | 4.12 [3.82;4.37] | 4.04 [3.76;4.35] | ns |
| Sodium (mmol/L) | 141 [139;143] | 141 [137;141] | 139 [136;143] | ns |
| Calcium (mmol/L) | 2.23 [2.16;2.29]* | 2.13 [2.05;2.23]* | 2.03 [1.97;2.11] | 0.000001 |
| Bicarbonate (mmol/L) | 26.3 [23.9;29.2] | 24.7 [22.6;27.2] | 25.7 [23.3;28.2] | ns |
Ns not significant, eGFR estimated glomerular filtration rate
Dunn’s post hoc test p < 0.05: * proteinuria category 3, $ with proteinuria category 1
Chi2 test for categorical variables with Bonferroni correction: * with proteinuria category 3