Table 3.
Clinical and biological characteristics of the patients at D0 according to tertiles of urinary α1-microglobulin at D0
| Tertile 1 < 32 mg/g (n = 51) |
Tertile 2 32–86 mg/g (n = 50) |
Tertile 3 > 86 mg/g (n = 52) |
Kruskal–Wallis test (or exact Chi2 test) | |
|---|---|---|---|---|
| Clinical | ||||
| Age (years) | 66 [57;80]* | 65 [58;73]* | 77 [70;85] | 0.005 |
| Women (%) | 49 | 34 | 33 | ns |
| Weight (kg) | 79 [65;94] | 83 [69;93] | 75 [68;90] | ns |
| Height (m) | 1.68 [1.61;1.79] | 1.74 [1.67;1.79] | 1.70 [1.65;1.76] | ns |
| Body Mass index (kg/m2) | 28 [25;31] | 28 [23;30] | 27 [23;29] | ns |
| Medical history | ||||
|
Hypertension (%) Diabetes (%) Chronic kidney disease (%) Active cancer (%) Active smoking(%) |
57 29 4* 8 6 |
62 18 8* 10 2 |
58 37 38 6 13 |
ns ns < 0.0001 ns ns |
| Intensive Care Unit (%) | 14 | 24 | 27 | ns |
| Severe cases (%) | 69* | 86 | 90 | 0.004 |
| Biological | ||||
|
Creatinine (D0)(mg/dL) eGFR (mL/min/1.73 m2) |
0.87 [0.70;0.99]* 82 [61;95]* |
0.91 [0.76;1.06] 82 [61;93]* |
1.04 [0.86;1.49] 61 [45;83] |
0.007 0.002 |
| C-reactive protein (mg/L) | 61 [15;108] | 135 [54;216]$ | 95 [47;147]$ | 0.0001 |
| Leukocyte count (/mm3) | 5940 [4260;5940] | 6720 [5170;10,100] | 6110 [4630;8615] | ns |
| Lymphocyte count (/mm3) | 925 [720;1350] | 850 [630;1050] | 820 [535;1095] | ns |
| Hemoglobin (g/dL) | 12.9 [12.0;14.0]* | 12.6 [11.6;13.7]* | 11.3 [10.5;13.0] | 0.0004 |
| Platelets (× 1000/mm3) | 248 [179;331]* | 247 [189;320]* | 180 [140;252] | 0.0007 |
| Lactate Dehydrogenase (U/L) | 288 [234;382] | 372 [274;531]$ | 361 [277;446]$ | 0.007 |
| D-Dimer (µg/L) | 972 [564;1590] | 1091 [789;3090] | 1050 [776;2208] | ns |
| Albumin (g/L) | 37 [33;40] | 33 [31;37]$ | 33 [29;36]$ | 0.0002 |
| Potassium (mmol/L) | 4.06 [3.76;4.40] | 4.09 [3.91;4.30] | 4.14 [3.72;4.48] | ns |
| Sodium (mmol/L) | 140 [138;143] | 138 [136;140] | 140 [137;143] | 0.04 |
| Calcium (mmol/L) | 2.18 [2.10;2.29] | 2.07 [2.00;2.16]$ | 2.07 [1.97;2.12]$ | 0.000004 |
| Bicarbonate (mmol/L) | 25.9 [23.2;27.5] | 24.5 [22.5;26.7] | 26.1 [23.6;28.9] | ns |
Ns not significant, eGFR estimated glomerular filtration rate
Dunn’s post hoc test p < 0.05: * proteinuria category stage 3, $ with proteinuria category 1
Chi2 test for categorical variables with Bonferroni correction: * with proteinuria category 3