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Conceptual model of the hypothesized relationships between social determinants, accelerated aging, and cardiovascular outcomes. Where “c” is the relationship between stressors and the outcome not adjusted for accelerated aging; “a” is the relationship between stressors and accelerated aging; “b” is the relationship between accelerated aging and the outcome; and “c’ ” (c-prime) is the relationship between stressors and the outcome adjusted for the mediator, accelerated aging.
