Fig. 3.

Unadjusted Mediation Model of Depression, Accelerated aging, and Stroke. a = pathway from depression to accelerated aging; b = pathway from accelerated aging to stroke; c = unadjusted pathway from depression to stroke; c’= pathway from depression to stroke adjusted for accelerated aging. Indirect effects = a*b; Direct effect = effects of depression on stroke in the presence of accelerated aging (c’); Total effects = indirect effect + direct effect. Numbers refer to standardized coefficient (bias-corrected 95% confidence interval) for each path.