Table 3.

Binary Mediation Coefficients for Accelerated aging at Y₂₀ (2005–2006) Mediating the Relationship between Social Factors at Y₁₅ (2000–2001) and Cardiovascular Disease after at Y₂₀ (2007–2016): CARDIA, 2000–2016*.

	Depression Score (Points, Continuous)		Socioeconomic Status Score (Points, Continuous)
Binary Mediation Resultsa	Unadjusted (95% CI)	Adjustedb (95% CI)	Unadjusted (95% CI)	Adjusted (95% CI)
Path a	0.12 (0.09, 0.16)	0.03 (-0.001,0.07)	-0.26 (-0.30, -0.22)	-0.09 (-0.13, -0.06)
Path b	0.25 (0.17, 0.33)	0.23 (0.13, 0.33)	0.23 (0.15, 0.32)	0.23 (0.13, 0.34)
a*b (indirect effect of X on Y)	0.03 (0.02, 0.04)	0.01 (0.001, 0.02)	-0.06 (-0.08, -0.04)	-0.02 (-0.03, -0.01)
Total Effect of X on Y	0.13 (0.06, 0.19)	0.09 (0.03, 0.16)	-0.15 (-0.23, -0.08)	-0.10 (-0.17, -0.02)
Percent total effect mediated (% indirect of total effect)	24.35%	7.82%	39.78%	22.52%

Note.

^aPath a = pathway from independent variable (depression score or SES score) to mediator (accelerated aging); Path b = pathway from mediator (accelerated aging) to outcome (cardiovascular disease). The coefficient for Path a corresponds to the association between the independent variable and the mediator; the coefficient for path b corresponds to the association between the mediator and the outcome; a*b corresponds to the effect of the mediation. 95% CI of a*b is bias-corrected and tests whether different than zero; The total effect of X on Y reports the indirect and direct effect of the independent variable on the outcome; percent total effect mediated is the percentage of the outcome that can be attributed to the mediator.

^bAdjusted for sex, chronological age, race, site, smoking status, and mL alcohol per week.