Table 1.

Parameters for Prediction of Mean IGF-I SDS (a, b) and Peak IGF-I SDS (c, d) in Adults With GHD and Children With GHD, Based on an IGF-I Sample Taken on Days 0–7 After Somapacitan Dose

a) Adults with GHD—mean IGF-I SDS
Day	Int	Slp.SDS	Slp.Dose	Slp.Dose_BW80	RSD	R2	PI 90% ±SDS
0	0.681	0.965	0.105	-0.00176	0.36	0.94	0.6
1	-0.282	0.959	-0.0400	0.000842	0.29	0.96	0.5
2	-0.334	0.936	-0.0585	0.00144	0.26	0.97	0.4
3	-0.242	0.947	-0.0317	0.000850	0.19	0.98	0.3
4	-0.0495	0.968	-0.000638	0.0000950	0.11	0.99	0.2
5	0.196	0.981	0.0330	-0.000625	0.14	0.99	0.2
6	0.450	0.980	0.0690	-0.00126	0.25	0.97	0.4
7	0.681	0.965	0.105	-0.00176	0.36	0.94	0.6
b) Children with GHD—mean IGF-I SDS
Day	Int	Slp.SDS	Slp.logDose	RSD	R 2		PI 90% ±SDS
0	1.24	0.950	0.353	0.29	0.94		0.5
1	-0.350	1.02	0.0990	0.28	0.95		0.5
2	-0.738	0.961	-0.0959	0.27	0.95		0.4
3	-0.609	0.936	-0.162	0.20	0.97		0.3
4	-0.208	0.917	-0.0926	0.16	0.98		0.3
5	0.293	0.912	0.0510	0.19	0.98		0.3
6	0.790	0.927	0.207	0.23	0.96		0.4
7	1.24	0.950	0.353	0.29	0.94		0.5
c) Adults with GHD—peak IGF-I SDS
Day	Int	Slp.SDS	Slp.Dose	Slp.Dose_BW80	RSD	R 2	PI 90% ±SDS
0	1.11	0.919	0.200	-0.00337	0.64	0.84	1.1
1	0.0742	1.02	0.0319	-0.000782	0.19	0.98	0.3
2	0.0149	0.997	0.0114	-0.000145	0.091	1.0	0.1
3	0.139	0.986	0.0462	-0.000795	0.22	0.98	0.4
4	0.362	0.982	0.0845	-0.00159	0.33	0.96	0.5
5	0.626	0.972	0.123	-0.00231	0.44	0.92	0.7
6	0.886	0.950	0.162	-0.00291	0.54	0.88	0.9
7	1.11	0.919	0.200	-0.00337	0.64	0.84	1.1
d) Children with GHD—peak IGF-I SDS
Day	Int	Slp.SDS	Slp.logDose	RSD	R 2		PI 90% ±SDS
0	2.10	0.866	0.562	0.51	0.84		0.8
1	0.534	1.05	0.239	0.18	0.98		0.3
2	0.118	1.00	0.0271	0.092	1.0		0.2
3	0.295	0.945	-0.00764	0.20	0.98		0.3
4	0.737	0.887	0.103	0.34	0.93		0.6
5	1.23	0.852	0.269	0.42	0.89		0.7
6	1.70	0.850	0.426	0.48	0.86		0.8
7	2.10	0.866	0.562	0.51	0.84		0.8

Abbreviations: GHD, growth hormone deficiency; IGF-I, insulin-like growth factor-I; int, intercept; PI, prediction interval; R², correlation coefficient; RSD, residual standard deviation; SDS, standard deviation score; slp.SDS, slope of insulin-like growth factor-I standard deviation score; slp.Dose, slope of dose; slp.logDose, slope of log dose; slp.Dose_BW80, slope of interaction between dose and body weight (normalized to 80 kg).