Table 2.

Associations Between Hepatic IGF-1 and IGF-Binding Protein mRNA and Baseline Hepatic and Glycemic Measures and Body Composition

	IGF1		IGFBP1		IGFBP2		IGFBP3		IGFBP4		IGFBP5		IGFBP6		IGFBP7
	r	P	r	P	r	P	r	P	r	P	r	P	r	P	r	P
Hepatic endpoints
Steatosis grade	−0.30	0.01	−0.47	0.08	−0.49	0.01	0.09	0.07	−0.12	0.01	0.04	0.59	0.25	0.004	0.35	<0.0001
NAFLD Activity Score	−0.33	0.04	−0.16	0.33	−0.23	0.16	0.14	0.39	−0.25	0.12	−0.05	0.76	0.47	0.003	0.83	<0.0001
Fibrosis stage	0.04b	0.66b	0.28	0.19	0.23	0.19	−0.04	0.30	0.04	0.27	−0.03	0.61	0.15	0.03	0.25	<0.0001
ALT (U/L)	−0.38	0.02	−0.13	0.45	−0.12	0.46	0.12	0.46	−0.15	0.35	−0.13	0.42	0.34	0.03	0.60	<0.0001
AST (U/L)	−0.38	0.02	−0.05	0.76	−0.04	0.83	0.05	0.78	−0.20	0.23	−0.18	0.28	0.33	0.04	0.64	<0.0001
Glycemic endpoints
Fasting Glucose (mg/dL)	−0.44	0.005	−0.32	0.05	−0.31	0.06	0.41	0.01	−0.28	0.08	0.21	0.20	0.28	0.09	0.40	0.01
Fasting Insulin (uIU/mL)	−0.46	0.005	−0.16	0.35	−0.20	0.24	0.28	0.10	−0.22	0.19	−0.02	0.89	0.27	0.11	0.64	<0.0001
Low-dose M (mg/kg/min)a	0.34	0.08	0.46	0.02	0.36	0.07	−0.37	0.06	0.50	0.007	0.09	0.65	−0.19	0.34	−0.10	0.63
Two-hour glucose after 75g glucose load (mg/d)	−0.34	0.03	−0.40	0.01	−0.22	0.17	0.30	0.06	−0.17	0.31	0.20	0.21	0.25	0.13	0.25	0.12
High-dose M (mg/kg/min)*	0.28	0.15	0.45	0.02	0.27	0.16	−0.30	0.12	0.38	0.04	0.17	0.38	−0.24	0.21	−0.18	0.37
Body composition
Body mass index (kg/m2)	−0.32	0.05	−0.51	0.001	−0.59	<0.0001	0.48	0.002	−0.48	0.002	−0.13	0.45	0.12	0.48	0.26	0.11
Visceral adipose tissue area (cm2)	−0.19	0.25	−0.25	0.13	−0.06	0.72	0.03	0.85	−0.16	0.33	−0.00	0.99	0.02	0.90	0.37	0.02
Subcutaneous adipose tissue area (cm2)	−0.20	0.24	−0.37	0.02	−0.46	0.004	0.34	0.04	−0.32	0.05	−0.22	0.19	0.08	0.63	0.06	0.72

For steatosis grade and fibrosis stage, r is slope in a 1-way ANOVA test for trend (from lowest to highest grade or stage) and P value is the P value for test for trend. For all other variables, r is Pearson’s correlation coefficient with corresponding P value.

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; IGF1, insulin-like growth factor-1; IGFBP, insulin-like growth factor–binding protein; M, glucose disposal.

^a Clamp data available for 28 subjects who participated at MGH.

^b Please refer to text for quadratic relationship between IGF1 mRNA and fibrosis stage.