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. 2020 Dec 9;106(2):e442–e459. doi: 10.1210/clinem/dgaa781

Table 4.

Medications associated with testicular failure

Impairment of Spermatogenesis
Chemotherapeutic agents
Calcium channel blockers
Colchicine
Sulphasalazine
Nitrofurantoin
Corticosteroids
Opioidsa
Radioiodine
Testosterone replacementa
Androgensa
Antiandrogenic
Cimetidine
Spironolactone
Flutamide
Ejaculatory failure
Alpha blockers
Serotonin reuptake inhibitors

a Treatment suppresses spermatogenesis by negative feedback on the hypothalamo–pituitary axis (hypogonadotropic hypogonadism).