Table 3.
Effect of various compounds on [3H]l-tryptophan uptake by TR-BBB cell lines.
Compounds | Concentration | Relative Uptake |
---|---|---|
mM | (% of Control) | |
Control | 100 ± 4 | |
+ Tryptophan | 2 | 7.27 ± 0.9 *** |
+ Phenylalanine | 2 | 8.68 ± 0.3 *** |
+ Tyrosine | 2 | 14.1 ± 1.0 *** |
+ Methionine | 2 | 10.3 ± 7.4 *** |
+ Glutamine | 2 | 19.4 ± 1.2 *** |
+ Citrulline | 2 | 27.3 ± 1.4 *** |
+ Valine | 2 | 38.4 ± 1.8 *** |
+ Cysteine | 2 | 41.3 ± 1.3 *** |
+ Lysine | 2 | 53.1 ± 4.1 *** |
+ Serine | 2 | 58.6 ± 1.5 *** |
+ Aspartic acid | 2 | 90.2 ± 3.4 |
+ Glutamic acid | 2 | 97.4 ± 3.8 |
+ Taurine | 2 | 102 ± 5 |
+ Choline | 2 | 110 ± 4 |
[3H]l-Tryptophan uptake by TR-BBB cell lines at 37 °C for 5 min in the presence or absence of l-type amino acids, taurine and choline at a concentration of 2 mM. Each value represents the mean ± SEM (n = 3–4). *** p < 0.001 denotes significantly different from control.