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. 2020 Dec 30;10(1):29. doi: 10.3390/antiox10010029

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of D-Aliophen^® against early preneoplastic lesions (aberrant crypt foci, ACF), polyps, and tumors induced in the colon of mice by azoxymethane (AOM) (A). Experimental design. Effect of D-Aliophen^® (3–300 mg/kg) on the formation of ACF (B), ACF ≥ 4 (C), polyps (D), and tumors (E) induced in the colon of mice by AOM (10 mg/kg). D-Aliophen^® was orally administered five times a week. The measurement of the parameters was performed 13 weeks after the first injection of AOM. Bar graphs represent the mean ± SD. Symbols indicate significance: # p < 0.01 or 0.001 vs. untreated, ** p < 0.01 and *** p < 0.001 vs. AOM (n = 5–10 mice).

Effect of D-Aliophen^® against early preneoplastic lesions (aberrant crypt foci, ACF), polyps, and tumors induced in the colon of mice by azoxymethane (AOM) (A). Experimental design. Effect of D-Aliophen^® (3–300 mg/kg) on the formation of ACF (B), ACF ≥ 4 (C), polyps (D), and tumors (E) induced in the colon of mice by AOM (10 mg/kg). D-Aliophen^® was orally administered five times a week. The measurement of the parameters was performed 13 weeks after the first injection of AOM. Bar graphs represent the mean ± SD. Symbols indicate significance: # p < 0.01 or 0.001 vs. untreated, ** p < 0.01 and *** p < 0.001 vs. AOM (n = 5–10 mice).