Table 1.
Demographics and clinical characteristics of healthy controls and premutation carriers with and without fragile X-associated tremor/ataxia syndrome (FXTAS).
| Characteristics | Controls (n = 16) | FXTAS− (n = 6) | FXTAS+ (n = 9) | F | p |
|---|---|---|---|---|---|
| Age (yr) | 53.13 (8.41) | 57.00 (6.20) | 63.33 (8.35) # | 4.645 | 0.018 * |
| Height (cm) | 167.61 (7.77) | 167.38 (12.76) | 165.14 (5.09) | 0.269 | 0.766 |
| Leg length (cm) | 86.31 (7.21) | 89.33 (5.78) | 85.93 (2.61) | 0.686 | 0.512 |
| Weight (kg) | 80.77 (16.41) | 82.56 (26.42) | 83.77 (25.11) | 0.060 | 0.941 |
| Male (n) φ | 8 | 2 | 3 | 0.883 | 0.643 |
| Full scale IQ | 106.63 (14.15) | 99.50 (8.14) | 102.67 (16.73) | 0.622 | 0.544 |
| CGG repeats | — | 74 (60–102) | 83 (58-107) | 0.416 | 0.531 |
| ICARS speech | — | 0 (0) | 0 (0–2) | 1.493 | 0.245 |
| ICARS kinetic | — | 0 (0) | 2 (1–7) † | 9.288 | 0.010 * |
| ICARS oculomotor | — | 0.5 (0–1) | 0 (0–3) | 0.468 | 0.507 |
| ICARS posture and gait | — | 1.5 (0–3) | 5 (1–7) † | 12.039 | 0.005 ** |
| ICARS total | — | 2 (0–4) | 8 (2–19) † | 9.510 | 0.009 ** |
Age, height, leg length, and weight are reported as (mean (SD)); CGG repeats and ICARS scores are reported as (median (range)). φ Chi-square statistics. # FXTAS+ group differs from healthy controls. † FXTAS+ group differs from FXTAS− group. * p < 0.05, ** p < 0.01. Bold highlight significant findings.