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. 2021 Jan 2;11(1):41. doi: 10.3390/brainsci11010041

Table 2.

Virtual Reality studies in aphasia recovery. Abbreviation: * RCT: randomized controlled trial; CS: case series; RGSa: Rehabilitation Gaming System for aphasia Interaction; VRRS-Tablet: Virtual Reality Rehabilitation System; RGS Rehabilitation Gaming System; VR: virtual reality.

Articles * Study Design Patients Task Technology Dose/Intensity Effects
Giachero et al., 2020 [119] RTC 36 chronic * Conversational Training Therapy (CTT) VR
(NeuroVR 2.0)
Two-hour therapy session, twice a week for 24 weeks. VR improved oral comprehension, repetition, written language, self-esteem, and emotional state
Marshall et al., 2020 [120] RTC 34 aphasics Group Therapy VR
(EVA Park)
Twenty-one hours therapy session for six months; sessions occurring once in a fortnight. No significant improvement in wellbeing, communicative success
Grechuta et al., 2019 [110] RTC 17 chronic Intensive Language-Action Therapy (ILAT) RGSa Five half-hour therapy session for eight weeks. Improvement in speech production, auditory comprehension, communicative effectiveness in everyday life, and lexical access
Maresca et al., 2019 [121] RTC 30 subacute Naming, composition, writing and rewriting VRRS-Tablet Five fifty-minutes sessions for two weeks. VRRS-Tablet Significant improved comprehension, repetition, reading, calculation, competence, adaptability, and self-esteem
Marshall et al., 2018 [122] CS 2 chronic Noun retrieval and Verb Network Strengthening VR
(EVA Park)
Twenty- one-hour therapy session over five weeks. VR improved noun retrieval
Carragher et al., 2018 [123] CS 3 chronic Storytelling VR
(EVA Park)
Twenty one-hour therapy session over five weeks. VR improved storytelling
Grechuta et al., 2017 [124] Longitudinal trial 4 chronic Sensorimotor speech therapy RGS Five forty- minutes therapy session over eight weeks. RGS improved word retrieval and verb execution
Marshall et al., 2016 [113] quasi-RTC 20 chronic Free communication VR
(EVA Park)
Twenty-five one-hour therapy session over five weeks. VR improved functional communication

* Acute (<four weeks post-onset); Sub-Acute (>four weeks post-onset); Chronic (>one year post-onset).