Table 7.
Selected Pfam domains and corresponding PSMs. The number of appearances of a certain PSM in the structure of a secondary metabolite is correlated to the number of Pfam domains found in the producing cluster. The descriptions are derived from the Pfam database. Pfam-derived abbreviations are: deoxythymidine diphosphate (dTDP), nicotinamide adenine dinucleotide (NAD), nucleoside diphosphate (NDP), uridine diphosphate glucose (UDP), guanosine diphosphate (GDP), flavin adenine dinucleotide (FAD), domain of unknown function (DUF).
| PSM | Pfam ID | Description | Pearson Correlation |
|---|---|---|---|
| Glyco | PF00908.16 | dTDP-4-dehydrorhamnose 3,5-epimerase | 0.67 |
| Glyco | PF01370.20 | NAD dependent epimerase/dehydratase family | 0.64 |
| Glyco | PF03559.13 | NDP-hexose 2,3-dehydratase | 0.61 |
| Glyco | PF00201.17 | UDP-glucoronosyl and UDP-glucosyl transferase | 0.59 |
| Glyco | PF03033.19 | Glycosyltransferase family 28 N-terminal domain | 0.56 |
| Glyco | PF01041.16 | DegT/DnrJ/EryC1/StrS aminotransferase family | 0.52 |
| Glyco | PF08421.10 | Putative zinc binding domain | 0.47 |
| Glyco | PF16363.4 | GDP-mannose 4,6 dehydratase | 0.44 |
| Glyco | PF04101.15 | Glycosyltransferase family 28 C-terminal domain | 0.28 |
| Glyco | PF01075.16 | Glycosyltransferase family 9 (heptosyltransferase) | 0.21 |
| Glyco | PF00728.21 | Glycosyl hydrolase family 20, catalytic domain | 0.18 |
| Glyco | PF02838.14 | Glycosyl hydrolase family 20, domain 2 | 0.18 |
| Glyco | PF01915.21 | Glycosyl hydrolase family 3 C-terminal domain | 0.13 |
| Glyco | PF00933.20 | Glycosyl hydrolase family 3 N terminal domain | 0.13 |
| Glyco | PF14885.5 | Hypothetical glycosyl hydrolase family 15 | 0.1 |
| Cl | PF04820.13 | Tryptophan halogenase | 0.66 |
| Cl | PF00999.20 | Sodium/hydrogen exchanger family | 0.51 |
| Spiroketal | PF12680.6 | SnoaL-like domain | 0.61 |
| Spiroketal | PF00890.23 | FAD binding domain | 0.54 |
| SS | PF07992.13 | Pyridine nucleotide-disulphide oxidoreductase | 0.46 |
| NO2 | PF01678.18 | Diaminopimelate epimerase | 0.67 |
| NO2 | PF06722.11 | Protein of unknown function (DUF1205) | 0.27 |
| 6-Ring | PF16197.4 | Ketoacyl-synthetase C-terminal extension | 0.53 |
| 6-Ring | PF02801.21 | Beta-ketoacyl synthase, C-terminal domain | 0.52 |
| 6-Ring | PF08990.10 | Erythronolide synthase docking | 0.51 |
| 6-Ring | PF00743.18 | Flavin-binding monooxygenase-like | 0.46 |
| 5-Ring | PF12680.6 | SnoaL-like domain | 0.56 |
| 5-Ring | PF00890.23 | FAD binding domain | 0.53 |
| 5-Ring | PF01551.21 | Peptidase family M23 | 0.46 |
| 5-Ring | PF08990.10 | Erythronolide synthase docking | 0.45 |
| 5-Ring | PF00486.27 | Transcriptional regulatory protein, C terminal | 0.26 |
| 5-Ring | PF16197.4 | Ketoacyl-synthetase C-terminal extension | 0.26 |
| 5-Ring | PF00109.25 | Beta-ketoacyl synthase, N-terminal domain | 0.26 |