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. 2020 Dec 24;10(1):17. doi: 10.3390/cells10010017

Figure 2.

Figure 2

Structural classification of SNX subfamilies. The domain architecture describes the functional domains within different SNX subfamilies. The phox homology (PX) domain denotes the highly conserved lipid-binding domain that unifies the SNX protein family. It enables SNXs to bind to specific phosphoinositides (PtdIns) which mark different membrane surfaces. SNX-BAR (Bin/Amphiphysin/Rvs) proteins contain coiled-coil regions that enhance membrane binding, membrane remodeling, and protein-protein interactions. PDZ (postsynaptic density 95/discs large/zonula occludens) domains, FERM (protein 4.1/ezrin/radixin/moesin) domains, SH3 (SRC homology 3) domains, MIT (microtubule interacting and trafficking) domains, and Kinesin motor domains play a role in membrane binding, substrate recognition, kinase activity regulation, protein trafficking, and binding/movement along microtubules. The color code signifies yeast and mammalian homologs.