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. 2020 Dec 25;14(1):14. doi: 10.3390/ph14010014

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Supramolecular carriers. (a) Structure of the arginine-based calix[4]arene 1 used in the transfection of PNAs; (b) fluorescence titration of Fluorescein-labelled PNAa221 directed against miR-221 (a221) by addition of increasing concentrations of calixarene 1 (from top to bottom: 0, 1.0, 2.0, 2.9, 3.9, 4.8, 5.7, 6.5, 7.4, 8.3, 9.1, 9.9 µM); (c) anti-miR 221 effect of transfected PNA a221 or its variant with octa-arginine CPP (R8-a221-PNA) in glioma U251 cells, in the absence and in the presence of calixarene 1, ** p < 0.01; (d) DNA tetrahedron for the delivery of PNA payloads in bacterial cells; (e) section of a complex containing a polyA-PNA and a thymine-modified nucleopeptide tested for the transfection of the former component in ref. [220]. Panels (a–c) are reprinted from [219]: Gasparello et al. © 2019 Creative Commons Attribution 4.0 International License.