Table 1.

The data obtained for 78 pre-selectedsingle-nucleotide polymorphisms(SNPs) [25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60] in patient groups with advanced and lowered target apremilast therapy clinical outcomes. SNP with statistically significant differences are labeled with a star *. The population was from European origin and were healthy. The“1000 Genomes” project is shown for reference.

Gene or Nearby Genomic Region	SNP Reference Sequence	Most Frequent Allele Variant	Minimal Frequency Allele Variants	Allele Frequency in Efficient Target Therapy Response Group	Allele Frequency in Lowered Target Therapy Response Group	Allele Frequency in the Population of European Origin	References
IL1A, IL1B	rs12469600	T	C	0.79	0.70	0.752	[25]
IL1B	rs1143633 *	C	T	0.46	0.70	0.666	[29]
IL1B	rs11676014	G	A	0.68	0.60	0.551	[26]
IL1B 2KB upstream	rs16944	G	A	0.75	0.55	0.65	[28]
IL1B 500B downstream	rs2853550	G	A	0.96	0.87	0.954	[28]
IL2 2KB upstream	rs2069762	A	C	0.75	0.62	0.708	[31]
IL2	rs2069778	G	A	0.64	0.77	0.849	[31]
IL-6	rs1800795	C	G	0.46	0.43	0.444	[32]
IL10 2KB upstream	rs1800871	G	A	0.79	0.62	0.76	[34]
IL10 2KB upstream	rs1800872	G	T	0.79	0.62	0.76	[34]
IL10 2KB upstream	rs1800896	T	C	0.50	0.62	0.547	[33]
IL10RA	rs947889	T	C	0.46	0.62	0.54	Live Ref SNPs
noncoding (IL-12B)	rs2082412	G	A	0.89	0.85	0.774	[35]
IL13, IL4	rs1800925	C	T	0.71	0.75	0.822	[36]
IL13, IL4	rs20541 *	G	A	0.57	0.80	0.793	[36]
IL4 2KB upstream	rs2243250	C	T	0.57	0.75	0.832	[59]
IL13 3′UTR	rs848	C	A	0.57	0.77	0.787	[36]
IL17A	rs10484879	G	T	0.93	0.82	0.75	[37]
IL17A 2KB upstream	rs2275913	G	A	0.75	0.55	0.62	[37]
IL-17F	rs763780	T	(C)	0.89	1	0.942	[37]
IL17RA: 2KB upstream	rs4819554	A	G	0.79	0.90	0.792	[37]
IL22	rs12307915	T	C	0.86	0.77	0.808	[58]
IL22 2kb upstream	rs2227473	C	T	0.86	0.77	0.81	[58]
IL22 2kb upstream	rs2227483	A	T	0.46	0.60	0.547	[58]
IL23R 500B downstream	rs9988642	T	C	0.96	0.95	0.928	[38]
IL23R	rs12564022	C	T	0.61	0.72	0.702	[60]
IL-23R	rs11209026	G	A	0.96	0.95	0.938	[42]
IL23R	rs2201841 *	A	G (T)	0.5	0.75	0.7	[35]
IL23R	rs2295359	G	A	0.64	0.55	0.686	[60]
IL23R	rs11209032	G	A	0.57	0.65	0.666	[42]
IL28RA	rs4649203	A	G	0.82	0.77	0.725	[48]
TYK2	rs12720356	A	C(G)	0.96	0.97	0.908	[43]
TYK2	rs280519	A	G(C)	0.50	0.55	0.505	[43]
TYK2	rs2304256	C	A	0.79	0.80	0.738	[43]
TYK2	rs34536443	G	C	1	1	0.971	[43]
PDE3A-SLC01C1	rs3794271	A	G	0.54	0.60	0.635	[44,45]
PDE4D (PART1)	rs152312	G	(A, T)	0.96	0.92	0.9	[46]
PDE4D	rs2910829	A	G	0.71	0.52	0.56	[46]
TNFa	rs1799724	C	T	0.79	0.82	0.906	[37]
TNFa	rs1799964	T	C	0.82	0.72	0.79	[47]
TNFa	rs1800629 *	G	A	0.82	0.97	0.866	[47]
TNF 2KB upstream	rs361525	G	A	0.93	0.92	0.936	[47]
TNFAIP3	rs610604	T	G	0.64	0.67	0.662	[37]
STAT1	rs2083482	T	C	0.71	0.62	0.496	[57]
STAT2	rs2020854	T	C	0.93	0.90	0.931	[53]
STAT2	rs2066807	C	G	0.93	0.90	0.933	[8]
STAT2	rs2066808	A	G	0.93	0.90	0.93	[58]
STAT3	rs2293152	C	G	0.50	0.60	0.596	[27]
STAT3	rs8074524	C	T	0.86	0.77	0.8	Live Ref SNPs
STAT3	rs744166	A	G	0.68	0.55	0.585	[56]
STAT4	rs7574865	G	T	0.71	0.85	0.77	[52]
STAT4	rs10181656	C	G	0.71	0.85	0.766	[52]
NFkB1	rs28362491	INS	DEL	0.54	0.60	0.595	[54]
NF-kB1A	rs2145623	G	C	0.82	0.70	0.724	[30]
NF-kB1A	rs8016947	T	G	0.50	0.47	0.471	[55]
NFkB1A	rs12586317	T	C	0.61	0.65	0.737	[41]
REL	rs62149416	T	C	0.61	0.80	0.636	[53]
REL	rs702873	C	T	0.50	0.70	0.553	[52]
RNF114	rs495337	G	A	0.61	0.62	0.602	[41]
ZNF313	rs2235617	C	G	0.61	0.65	0.602	[39]
REV3L	rs240993	C	A	0.71	0.55	0.712	[30]
IFNG	rs2430561	A	T	0.54	0.40	0.462	[51]
CAST, ERAP1	rs27524	G	A	0.54	0.65	0.634	[48]
HLA-C	rs4406273	G	A	0.79	0.72	0.902	[50]
NOS2	rs4795067	A	G	0.50	0.57	0.641	[41]
CYP3A5	rs776746	C	T	1	0.92	0.943	PharmGKB
TSC1	rs1076160	C	T	0.71	0.52	0.489	[55]
FBXL19	rs10782001	A	G	0.54	0.62	0.641	[41]
KCNH7	rs17716942	T	C	0.96	0.90	0.839	[39]
ANXA6	rs17728338	G	A	0.96	0.87	0.93	[35]
HCP5	rs2395029	T	G	0.93	0.92	0.956	[40]
COG6	rs7993214	C	T(G)	0.57	0.62	0.657	[40]
SDC4	rs1008953	C	T	0.86	0.72	0.775	[41]
RPS26	rs12580100	A	G	0.93	0.85	0.867	[41]
NONE	rs1975974	A	G	0.82	0.77	0.763	[41]
LCE3D	rs4112788	G	A	0.68	0.62	0.644	[8]
LOC105376976	rs6809854	A	G	0.64	0.77	0.802	[41]
LOC107984144	rs10484554	C	T	0.68	0.60	0.857	[40]