Table 3.
The number of methylated markers in cfDNA samples in relation to clinicopathological features of colorectal cancer patients (n = 97).
| n | Mean | S.D. | p-Value ** | ||
|---|---|---|---|---|---|
| Tumor subsite | Right colon | 15 | 1.73 | 1.438 | 0.675 |
| Left colon | 63 | 2.02 | 1.314 | ||
| Rectum | 19 | 1.89 | 1.243 | ||
| Differentiation * | WD | 8 | 1.13 | 1.126 | 0.051 |
| MD | 79 | 1.95 | 1.300 | ||
| PD | 10 | 2.55 | 1.265 | ||
| Lymphatic emboli | Absent | 57 | 1.60 | 1.193 | 0.001 |
| Present | 40 | 2.45 | 1.319 | ||
| Venous invasion | Absent | 77 | 1.71 | 1.037 | 0.011 |
| Present | 20 | 2.85 | 1.814 | ||
| Perineural invasion | Absent | 60 | 1.68 | 1.157 | 0.028 |
| Present | 37 | 2.38 | 1.441 | ||
| T category | 1 | 8 | 1.13 | 0.991 | 0.001 |
| 2 | 17 | 1.41 | 0.870 | ||
| 3 | 53 | 1.87 | 1.225 | ||
| 4 | 19 | 3.00 | 1.414 | ||
| N category | 0 | 44 | 1.48 | 0.849 | 0.007 |
| 1 | 33 | 2.24 | 1.480 | ||
| 2 | 20 | 2.50 | 1.539 | ||
| M category | 0 | 74 | 1.53 | 0.996 | <0.001 |
| 1 | 23 | 3.30 | 1.295 | ||
| Stage | I | 17 | 1.24 | 0.831 | <0.001 |
| II | 24 | 1.67 | 0.816 | ||
| III | 33 | 1.58 | 1.173 | ||
| IV | 23 | 3.30 | 1.295 |
* WD, well-differentiated; MD, moderately differentiated; PD, poorly differentiated. ** For the comparison between two groups or three or more groups, the Mann–Whitney test and Kruskal–Wallis test were used, respectively.