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. 2020 Dec 29;10(1):25. doi: 10.3390/antiox10010025

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Proteomic analysis of H₂O_2-treated ARPE cells. (A) the scatter plot reports the identified proteins ranked according to intensity values, ~3000 protein groups were identified in ARPE-19 cells, across six orders of magnitude; (B) Volcano plot of the differentially expressed proteins upon H₂O₂ treatment. A total of 148 proteins were up-regulated by H₂O₂ treatment, while 141 showed down-regulation as compared to control samples; (C,D) Network analysis of DE proteins after H₂O₂ treatment. Networks were retrieved using the STRING database and visualised using the Cytoscape software. Functional enrichment was used to understand which biological processes were enriched in each cluster.