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. 2020 Dec 30;13(1):39. doi: 10.3390/pharmaceutics13010039

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Chronic convection enhanced delivery (CED) of topotecan provides a significant survival advantage. Rats with orthotopic virally-induced, platelet derived growth factor (PDGF) driven tumors were treated with CED of topotecan for various days (1, 4, or 7 days). p-values show a comparison to the PBS control. 1, 4, and 7 days CED survival were each significantly greater than PBS (p < 0.05). The median survival for 7 days CED was significantly greater than the other groups, (median survival: PBS—20 dpi, 1 day—23 dpi, 4 day—31 dpi, 7 day—54 dpi; p < 0.05). The figure is reproduced with permission from [35], Cancer Res. 2011.